303-69-5

• 常用中文名：丙硫喷地
• 常用英文名：Prothipendyl
• CAS号：303-69-5
• 分子式：C₁₆H₁₉N₃S
• 分子量：285.40700
• 发布时间：2018-04-19 08:00:00
• 更新时间：2025-08-25 13:22:45

名称

• 中文名: 丙硫喷地
• 英文名: N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine
• 英文别名: Prothipendyl; Prothipendylum [INN-Latin]; Prothipendyl [INN:BAN]; LG 206; Largophren; Protipendilo [INN-Spanish]; (3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin; Tumovan; Timoval; (3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine; Timovan; Dominal; 10-<3-Dimethylamino-propyl>-4-aza-phenothiazin

物化性质

• 密度: 1.168g/cm3
• 沸点: 430.8ºC at 760mmHg
• 分子式: C₁₆H₁₉N₃S
• 分子量: 285.40700
• 闪点: 214.3ºC
• 精确质量: 285.13000
• PSA: 44.67000
• LogP: 3.70100
• 折射率: 1.621

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU8576000 CHEMICAL NAME : 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)- CAS REGISTRY NUMBER : 303-69-5 BEILSTEIN REFERENCE NO. : 0259865 LAST UPDATED : 199706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C16-H19-N3-S MOLECULAR WEIGHT : 285.44 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 18,373,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 415 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 135 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 102 mg/kg TOXIC EFFECTS : Behavioral - antipsychotic REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,374,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3040 mg/kg/22W-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

安全

• 海关编码: 2934999090

合成路线

261-96-1 109-54-6 ~% 303-69-5

文献：Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

95873-97-5 ~% 303-69-5

文献：Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

92316-06-8 ~% 303-69-5

文献：Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

91902-18-0 ~% 303-69-5

文献：Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

137-07-5 ~% 303-69-5

文献：Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

6631-37-4 ~% 303-69-5

文献：Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

124-40-3 109-70-6 ~% 303-69-5

文献：DEGUSSA Patent: DE1014544 , 1956 ;

上下游产品

上游产品  8
261-96-1 109-54-6 92316-06-8 91902-18-0
137-07-5 6631-37-4 124-40-3 109-70-6
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%