Prothipendyl

Modify Date: 2025-08-25 13:22:45

Prothipendyl Structure
Prothipendyl structure
 Common Name Prothipendyl
CAS Number 303-69-5 Molecular Weight 285.40700
Density 1.168g/cm3 Boiling Point 430.8ºC at 760mmHg
Molecular Formula C16H19N3S Melting Point N/A
MSDS N/A Flash Point 214.3ºC

 Names

Name N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.168g/cm3
Boiling Point 430.8ºC at 760mmHg
Molecular Formula C16H19N3S
Molecular Weight 285.40700
Flash Point 214.3ºC
Exact Mass 285.13000
PSA 44.67000
LogP 3.70100
Index of Refraction 1.621
InChIKey JTTAUPUMOLRVRA-UHFFFAOYSA-N
SMILES CN(C)CCCN1c2ccccc2Sc2cccnc21

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8576000
CHEMICAL NAME :
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-
CAS REGISTRY NUMBER :
303-69-5
BEILSTEIN REFERENCE NO. :
0259865
LAST UPDATED :
199706
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H19-N3-S
MOLECULAR WEIGHT :
285.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 18,373,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
415 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,374,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3040 mg/kg/22W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Prothipendyl
Prothipendylum [INN-Latin]
Prothipendyl [INN:BAN]
LG 206
Largophren
Protipendilo [INN-Spanish]
(3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin
Tumovan
Timoval
(3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine
Timovan
Dominal
10-<3-Dimethylamino-propyl>-4-aza-phenothiazin
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