21018-84-8

• 常用中文名：苦龙胆酯苷
• 常用英文名：Amarogentin
• CAS号：21018-84-8
• 分子式：C₂₉H₃₀O₁₃
• 分子量：586.541
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-04-09 08:00:00
• 更新时间：2024-01-03 14:14:08
• Amarogentin 是一种裂环烯醚萜苷,主要从 Swertia 和 Gentiana 根中提取。Amarogentin 表现出许多生物学效应,包括抗氧化,抗肿瘤和抗糖尿病活性。 Amarogentin 具有保肝和免疫调节作用。Amarogentin 促进细胞凋亡,阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。Amarogentin 通过激活 AMPK 发挥有益的血管代谢作用。

名称

• 中文名: 苦龙胆脂甙
• 英文名: amarogentin
• 中文别名: 苦龙胆酯苷,苦杏苷; 苦杏苷; 苦龙胆酯苷
• 英文别名: (4aS,5R,6S)-1-Oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-β-D-glucopyranoside; (4aS,5R,6S)-5-ethenyl-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-β-D-glucopyranoside; amorogentin; sweroside-2'-O-3",5",3'''-trihydroxy-biphenyl-2''-carboxylic acid; [4aS-(4aa,5b,6a)]-3,3',5-Trihydroxy[1,1'-biphenyl]-2-carboxylic Acid 2-Ester with 5-Ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one; Sweroside-2'-(3'',5'',3'''-trihydroxydiphenyl)-2''-carboxylic Acid Ester; amarosgentin; Amarogentin Hydrate; (4aS,5R,6S)-1-Oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl 2-O-[(3,3',5-trihydroxy-2-biphenylyl)carbonyl]-β-D-glucopyranoside; 1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-4,4a,5,6-tetrahydro-6-((2-O-((3,3',5-trihydroxy(1,1'-biphenyl)-2-yl)carbonyl)-β-D-glucopyranosyl)oxy)-, (4aS,5R,6S)-; 1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-4,4a,5,6-tetrahydro-6-[[2-O-[(3,3',5-trihydroxy[1,1'-biphenyl]-2-yl)carbonyl]-β-D-glucopyranosyl]oxy]-, (4aS,5R,6S)-; Amarogentin

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 928.5±65.0 °C at 760 mmHg
• 熔点: 229-230ºC
• 分子式: C₂₉H₃₀O₁₃
• 分子量: 586.541
• 闪点: 306.9±27.8 °C
• 精确质量: 586.168640
• PSA: 201.67000
• LogP: 2.79
• 外观性状: 白色粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.693
• 储存条件: -20C

生物活性

• 描述: Amarogentin 是一种裂环烯醚萜苷,主要从 Swertia 和 Gentiana 根中提取。Amarogentin 表现出许多生物学效应,包括抗氧化,抗肿瘤和抗糖尿病活性。 Amarogentin 具有保肝和免疫调节作用。Amarogentin 促进细胞凋亡,阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。Amarogentin 通过激活 AMPK 发挥有益的血管代谢作用。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zhang Y, et al. Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Molecules. 2017 May 6;22(5). pii: E754.

  [2]. Wölfle U, et al. Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes. Mediators Inflamm. 2015;2015:630128.

  [3]. Zhao JG, et al. Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. J BUON. 2016 May-Jun;21(3):609-17.