上海化源生化科技有限公司
上海市上海市普陀区
产品名：异卡波肼
纯度：98.0%
规格：
联系人：徐经理
联系电话：133 1186 9306

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：Isocarboxazid
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Isocarboxazid
纯度：98.0%
规格：5mg/100mg/25mg/25mg
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：异卡波肼
纯度：98.0%
规格：100mg
联系人：阿拉丁
联系电话：400-620-6333

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59-63-2生产厂家

59-63-2价格

59-63-2

59-63-2结构式

常用中文名：异卡波肼
常用英文名：Isocarboxazid
CAS号：59-63-2
分子式：C₁₂H₁₃N₃O₂
分子量：231.251
相关类别：医药中间体 OLED材料中间体
发布时间：2018-05-22 08:00:00
更新时间：2025-08-24 08:54:14
Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。

化源商城直购

中文名	异卡波肼
英文名	N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
中文别名	异恶唑酰肼
英文别名	isocarboxazide Benazide 5-Methyl-isoxazol-3-carbonsaeure-(N'-benzyl-hydrazid) Marplan Isocarboxazidum N'-Benzyl-5-methylisoxazol-3-carbohydrazid Isocarboxazida 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide N'-benzyl-5-méthylisoxazole-3-carbohydrazide Isocarbonazid Isocarboxazid N'-benzyl-5-methylisoxazole-3-carbohydrazide N-Benzyl-N'-<5-methyl-isoxazol-3-yl>-carbonyl-hydrazin Isocarbossazide N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide Isocarboxyzid Enerzer 5-methyl-isoxazole-3-carboxylic acid-(N'-benzyl-hydrazide) isocarboxacid 5-methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide

描述	Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50 值为4.8 μM。
相关类别	信号通路 >> 神经信号通路 >> 单胺氧化酶研究领域 >> 神经疾病
靶点	IC50: 4.8 μM (rat brain monoamine oxidase)[1].
体内研究	在小鼠中预处理Isocarboxazid(1,3 mg/kg,腹膜内注射,60分钟)显示5-HTP后15和30分钟时头部抽搐的数量显着增加[2]。与单独使用5-HTP的小鼠相比,小鼠中的Isocarboxazid(1,3 mg/kg,ip,60 min)处理与5-HTP一起施用导致43％的5-HT浓度增加和22％的5-HIAA降低[2]。动物模型：12只雄性小鼠dd株(20-25g)[2]剂量：0,0.3,1,3mg/kg给药：腹腔注射60分钟,静脉注射5-HTP结果：头部抽搐数量5-HTP增加后15和30分钟。 43％的5-HT浓度增加,22％的5-HIAA减少。
参考文献	[1]. MAXWELL DR, et al. Relative activity of some inhibitors of mono-amine oxidase in potentiating the action of tryptamine in vitro and in vivo. Br J Pharmacol Chemother. 1961 Dec;17:310-20.

密度	1.2±0.1 g/cm3
沸点	394.5±42.0 °C at 760 mmHg
熔点	98-100ºC
分子式	C₁₂H₁₃N₃O₂
分子量	231.251
闪点	192.4±27.9 °C
精确质量	231.100784
PSA	67.16000
LogP	1.03
蒸汽压	0.0±0.9 mmHg at 25°C
折射率	1.573
储存条件	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY2625000

CHEMICAL NAME :: 3-Isoxazolecarboxylic acid, 5-methyl-, 2-benzylhydrazide

CAS REGISTRY NUMBER :: 59-63-2

BEILSTEIN REFERENCE NO. :: 0201295

LAST UPDATED :: 199612

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C12-H13-N3-O2

MOLECULAR WEIGHT :: 231.28

WISWESSER LINE NOTATION :: T5NOJ C1 EVMM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4800 ug/kg/21W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 199 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >40 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 130 mg/kg

SEX/DURATION :: female 10-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 2,209,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6269 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)

符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	Missing Phrase - N15.00950417
危险品运输编码	UN 3249
包装等级	III
危险类别	6.1(b)
海关编码	2934999090

19788-35-3

20570-96-1

59-63-2

文献：Journal of Heterocyclic Chemistry, , vol. 46, # 5 p. 909 - 913

91397-11-4

59-63-2

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 2, p. 133 - 145

62438-03-3

59-63-2

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 2, p. 133 - 145

100-52-7

59-63-2

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 2, p. 133 - 145

19788-35-3

555-96-4

59-63-2

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 2, p. 133 - 145 US2908688 , ;

上游产品 6
19788-35-3 20570-96-1 91397-11-4 62438-03-3
100-52-7 555-96-4
下游产品 1
491594-42-4

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

59-63-2	17391-09-2
3019-51-0	66195-31-1
1013621-79-8	126040-58-2
9003-97-8	56180-94-0
1221158-13-9	66608-32-0
898412-33-4	898457-74-4
898412-34-5	898431-64-6
898431-65-7	898457-76-6
898412-36-7	898431-66-8
898457-77-7	898412-37-8

59-63-2

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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