1041434-82-5

• 常用中文名：帕拉米韦
• 常用英文名：Peramivir Trihydrate
• CAS号：1041434-82-5
• 分子式：C₁₅H₃₄N₄O₇
• 分子量：382.453
• 相关类别： 信号通路 抗感染 流感病毒
• 发布时间：2018-04-17 08:00:00
• 更新时间：2024-01-01 23:33:39
• Peramivir (RWJ 270201; Rapiacta; BCX 1812)是高活性的流感病毒神经氨酸苷酶抑制剂,IC50的中位值为0.09 nM。

名称

• 中文名: 帕拉米韦
• 英文名: peramivir
• 中文别名: 帕拉米韦三水合物
• 英文别名: Rapiacta trihydrate; Peramivir Trihydrate; QW7Y7ZR15U; peramivir hydrate; BCX 1812 trihydrate; CS-0732; UNII-QW7Y7ZR15U; (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid,trihydrate; (1S,2S,3S,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxycyclopentanecarboxylic acid trihydrate; Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxy-, (1S,2S,3S,4R)-, hydrate (1:3)

物化性质

• 分子式: C₁₅H₃₄N₄O₇
• 分子量: 382.453
• 精确质量: 382.242737
• PSA: 179.71000
• LogP: 1.69890
• 外观性状: 固体;White to Almost white powder to crystal
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热
• 水溶解性: 水溶性：微溶；极微溶：乙醇,甲醇；不溶：二甲基甲酰胺

生物活性

• 描述: Peramivir (RWJ 270201; Rapiacta; BCX 1812)是高活性的流感病毒神经氨酸苷酶抑制剂,IC50的中位值为0.09 nM。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 参考文献:

  [1]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM.Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09.PLoS One. 2012;7(6):e40261.

  [2]. Sakata H.Clinical efficiency in children treated with intravenous drip infusion of peramivirJpn J Antibiot. 2011 Dec;64(6):383-7.

  [3]. Abed Y, Pizzorno A, Boivin G.Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation.Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80.

  [4]. Shobugawa Y, Saito R, Sato I, Kawashima T, Dapat C, Dapat IC, Kondo H, Suzuki Y, Saito K, Suzuki H.Clinical effectiveness of neuraminidase inhibitors-oseltamivir, zanamivir, laninamivir, and peramivir-for treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: an observational study in the 2010-2011 influenza season in Japan.J Infect Chemother. 2012 May 29.

  [5]. Yu Y, Garg S, Yu PA, Kim HJ, Patel A, Merlin T, Redd S, Uyeki TM.Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under emergency use authorization, October 2009-June 2010.Clin Infect Dis. 2012 Jul;55(1):8-15.

安全

• 危害码 (欧洲): Xi