111011-63-3

• 常用中文名：依福地平
• 常用英文名：Efonidipine
• CAS号：111011-63-3
• 分子式：C₃₄H₃₈N₃O₇P
• 分子量：631.655
• 相关类别： 信号通路 跨膜转运 钙通道
• 发布时间：2018-10-02 22:41:42
• 更新时间：2024-01-03 19:31:44
• Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。

名称

• 中文名: 依福地平
• 英文名: 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
• 英文别名: 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, (4S)-; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate; Efonidipine HCl; 3-(benzyl-(phenyl)amino)ethyl-5-(5,5-dimethyl-2-oxo-1,3-dioxaphosphorinane-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine; 2-[Benzyl(phenyl)amino]ethyl (4S)-5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylate; Efonidipine [INN]; Efonidipine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 746.9±60.0 °C at 760 mmHg
• 分子式: C₃₄H₃₈N₃O₇P
• 分子量: 631.655
• 闪点: 405.5±32.9 °C
• 精确质量: 631.244751
• PSA: 132.73000
• LogP: 6.99
• 外观性状: 粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.625
• 储存条件: -20℃

生物活性

• 描述: Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71.

  [2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92.

  [3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6.

  [4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

合成路线

1005-69-2 ~% 111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

111011-80-4 ~% 111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

126-30-7 ~% 111011-63-3

文献：Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2362 - 2369

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