118244-44-3

• 常用中文名：泼尼松龙法呢酯
• 常用英文名：Prednisolone Farnesylate
• CAS号：118244-44-3
• 分子式：C₃₆H₅₀O₆
• 分子量：578.77900
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-02-22 08:00:00
• 更新时间：2024-01-05 18:54:04
• PNF21 是一种经皮激素,具有抗炎活性。

名称

• 中文名: 泼尼松龙法呢酯
• 英文名: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoate
• 中文别名: 泼尼松龙法呢酸酯
• 英文别名: Prednisolone farnesylate; Pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10-dodecatrienyl)-oxy)-,(11beta,21(2E,6E)); Farnerate gel; Farnerate (TN); Farnezone; PNF21

物化性质

• 密度: 1.15g/cm3
• 沸点: 712.5ºC at 760mmHg
• 分子式: C₃₆H₅₀O₆
• 分子量: 578.77900
• 闪点: 217.5ºC
• 精确质量: 578.36100
• PSA: 100.90000
• LogP: 6.52770
• 蒸汽压: 1.88E-23mmHg at 25°C
• 折射率: 1.569
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: PNF21 是一种经皮激素,具有抗炎活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: PNF21(泼尼松龙法尼醇,PNF-21)是一种合成的糖皮质激素,它是泼尼松龙及其酯法戊烯酸酯的化合物,已知可抑制佐剂诱导的关节炎的局部肿胀[1]。
• 参考文献:

  [1]. Kato N, et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. J Neurol Sci. 2002 Oct 15;202(1-2):69-74.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3832200 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10- dodecatrienyl)-oxy)-, (11beta,21(2E,6E))- CAS REGISTRY NUMBER : 118244-44-3 LAST UPDATED : 199306 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C36-H50-O6 MOLECULAR WEIGHT : 578.86 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1456 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),49,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 728 mg/kg/52W-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - changes in spleen weight Biochemical - Metabolism (Intermediary) - other proteins REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),91,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2730 mg/kg/13W-I TOXIC EFFECTS : Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),1,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 291 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),123,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 291 mg/kg/52W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Blood - changes in leukocyte (WBC) count Biochemical - Metabolism (Intermediary) - other proteins REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),161,1992 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : >11 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - hepatobiliary system REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),217,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3250 ug/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),241,1992