156223-05-1

• 常用中文名：GTS-21二盐酸盐(DMBX-A)
• 常用英文名：GTS-21
• CAS号：156223-05-1
• 分子式：C₁₉H₂₂Cl₂N₂O₂
• 分子量：381.30
• 相关类别： 信号通路 跨膜转运 胆碱受体
• 发布时间：2018-12-30 12:15:26
• 更新时间：2026-07-01 13:45:07
• GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。

名称

• 中文名: (1:2),(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3-联吡啶盐酸盐
• 英文名: 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
• 中文别名: GTS-21盐酸盐; GTS-21二盐酸盐; 化合物：GTS 21 dihydrochloride; GTS-21 DIHYDROCHLORIDE (DMBX-A),ALPHA7 NICOTINIC ACETYLCHOLINE RECTOR激动剂; (3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐; 化合物:GTS 21 dihydrochloride; (E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐; (E)-3-(2,4-二甲氧基苄亚基)-3,4,5,6-四氢-2,3'-联吡啶 盐酸盐
• 英文别名: (E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride; 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride; DMXB-A; GTS 21 2HCl; (3E)-3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine dihydrochloride; DMBX-anabaseine; GTS 21 DIHYDROCHLORIDE;DMXB-A;DMBX-ANABASEINE; GTS-21 (hydrochloride); GTS-21HCl; Dihydrochloride / 3-(2,4-dimethoxybenzylidene)anabaseine; inhibit,5-hydroxytryptamine Rector,antiinflammatory,cognition,GTS-21,nAChR,GTS21 dihydrochloride,Serotonin Rector,fibrosis,Inhibitor,GTS 21,5-HT Rector,Nicotinic acetylcholine rectors,lung,injury,GTS21,pulmony; GTS-21 dihydrochloride (DMBX-A); GTS-21 dihydrochloride, 10 mM in DMSO; 3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine; GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine rector agonist; GTS21;GTS 21;GTS-21; 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine Dihydrochloride; 3-(2,4-DiMethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl Dihydrochloride; GTS-21 (DMBX-A); 3-(2,4-dimethoxybenzylidene)anabaseine / / 156-1 in sock; (3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine; GTS-21 (dihydrochloride); GTS 21 2HCl(DMXBA); DMBX-A; 3-(2,4-dimethoxybenzylidene)anabaseine; (E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine hydrochloride; 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride; GTS 21 dihydrochloride(DMXB-A); GTS-21 (DMXB-A); GTS 21 dihydrochloride; GTS 21 2hydrochloride; 3-(2,4)-DiMethoxybenzylidineanabaseine

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 485.6±45.0 °C at 760 mmHg
• 熔点: 216-217℃ (decomposition)
• 分子式: C₁₉H₂₂Cl₂N₂O₂
• 分子量: 381.30
• 闪点: 247.5±28.7 °C
• PSA: 43.71000
• LogP: 2.64
• 外观性状: powder,faint yellow to dark yellow
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 2-8°C
• 水溶解性: H2O: >5mg/mL

生物活性

• 描述: GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Yue Y, et al. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-12.

  [2]. Nullens S, et al. EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. Shock. 2016 Apr;45(4):450-9.

安全

• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: DW1764860
• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%