135042-17-0

• 常用中文名：N-Boc-(2R,4S)--4-羟基-D-脯氨酸甲酯
• 常用英文名：Boc-trans-D-Hyp-OMe
• CAS号：135042-17-0
• 分子式：C₁₁H₁₉NO₅
• 分子量：245.272
• 相关类别： 生物化工 氨基酸及其衍生物 脯氨酸类衍生物
• 发布时间：2019-01-09 12:50:43
• 更新时间：2026-07-05 17:52:39
• Boc-trans-D-Hyp-OMe是一种不可切割的ADC连接物,用于合成抗体药物结合物(ADC)。Boc-trans-D-Hyp-OMe也是一种基于烷基链的PROTAC连接剂,可用于合成PROTAC[1][2]。

名称

• 中文名: N-BOC-反式-4-羟基-D-脯氨酸甲酯
• 英文名: (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
• 中文别名: N-BOC-反式-4-羟基-D-脯氨酸甲基酯; N-BOC-D-4-羟基-脯氨酸甲酯; (2R,4S)-4-羟基吡咯烷-1,2-二羧酸-1-叔丁酯-2-甲酯; N-BOC-反式-4-羟基-D; BOC-反式-4-羟基-D-脯氨酸甲酯; (2R,4S)-1-BOC-4-羟基吡咯烷-2-甲酸甲酯; (2R,4S)-4-羟基吡咯烷-1,2-二羧酸1-叔丁基2-甲酯; 2-甲基(2R,4S)-4-羟基吡咯烷-1-甲基-1,2-二羧酸1-叔丁酯; 反式-4-羟基-D-脯氨酸甲酯; (2R,4S)-4-羟基吡咯烷-1,2-二羧酸 1-叔丁酯 2-甲酯; BOC-TRANS-D-HYP-OME (N-BOC-反式-4-羟基-D-脯氨酸甲酯); N-BOC-(2R,4S)-4-羟基-D-脯氨酸甲酯
• 英文别名: N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER //BP; (Tert-Butoxy)carbonyl D-trans-Hyp-OMe; N-Boc-trans-D-Hyp-Ome; Methyl (2R,4S)-1-Boc-4-hydroxypyrrolidine-2-cboxylate; trans-Boc-D-Hpy-Ome; 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S); 1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate; 1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate; (4S)-4-Hydroxy-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline; (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicboxylate; N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER (CAS NO.135-0); (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate; (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-Methyl ester (N-Boc-trans-4-Hydroxy-D-proline Methyl ester; N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER; 1-(tert-Butyl) 2-methyl (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate; N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este; N-Boc-Trans-5-Hydroxy-D-Proline Methyl Ester; N-tert-butoxycbonyl-trans-4-hydroxy-D-proline Methyl ester; (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-methyl; 1-tert-butyl 2-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicboxylate; Boc-trans-4-Hydroxy-D-proline Methyl ester; (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicboxylate/N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER; Boc-D-trans-Hyp-OMe; 1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; (2R,4S)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-methyl ester; (2R,4S)-N-Boc-trans-4-hydroxy-D-proline methyl ester; Methyl (4S)-1-Boc-4-hydroxy-D-prolinate; (2R,4S)-N-Boc-4-hydroxyproline methyl ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 387.6±42.0 °C at 760 mmHg
• 分子式: C₁₁H₁₉NO₅
• 分子量: 245.272
• 闪点: 188.2±27.9 °C
• 精确质量: 245.126328
• PSA: 76.07000
• LogP: -0.17
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.520
• 储存条件: 2-8°C

生物活性

• 描述: Boc-trans-D-Hyp-OMe是一种不可切割的ADC连接物,用于合成抗体药物结合物(ADC)。Boc-trans-D-Hyp-OMe也是一种基于烷基链的PROTAC连接剂,可用于合成PROTAC[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗体- 药物偶联物 >> ADC连接器
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 靶点:

  Non-cleavable

• 体外研究: ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。PROTAC包含两个不同的配体,通过连接体连接；一个是E3泛素连接酶的配体,另一个是靶蛋白的配体。PROTAC利用细胞内泛素-蛋白酶体系统选择性降解目标蛋白质[2]。
• 参考文献:

  [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

  [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

安全

• 危害码 (欧洲): Xi

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