999-61-1

• 常用中文名：2-丙烯酸-2-羟基丙基酯
• 常用英文名：2-HYDROXYPROPYL ACRYLATE
• CAS号：999-61-1
• 分子式：C₆H₁₀O₃
• 分子量：130.14200
• 相关类别： 研究领域 其他
• 发布时间：2018-08-10 19:54:28
• 更新时间：2024-01-02 15:26:39
• 丙烯酸2-羟丙酯(HPA)对皮肤具有严重刺激性和腐蚀性。2-羟丙基丙烯酸酯(HPA)广泛应用于纤维、粘合剂、橡胶工业、油漆和涂料工业[1][2]。

名称

• 中文名: 丙烯酸羟丙酯
• 英文名: 2-Hydroxypropyl acrylate
• 中文别名: 丙烯酸2-羟丙酯; 2-丙烯酸-2-羟基丙基酯
• 英文别名: MFCD00021900; 2-hydroxypropyl acrylate; EINECS 213-663-8

物化性质

• 密度: 1.049 g/cm3
• 沸点: 77°C 5mm
• 分子式: C₆H₁₀O₃
• 分子量: 130.14200
• 闪点: 79.9ºC
• 精确质量: 130.06300
• PSA: 46.53000
• LogP: 0.09640
• 外观性状: 液体
• 折射率: 1.442
• 储存条件: 室温
• 稳定性:

  本品有毒。皮肤或眼睛接触时，会引起突症。生产操作必须备有防毒面具。工作环境容许浓度为3mg/m3.

• 分子结构:

  1、 摩尔折射率：32.83

  2、 摩尔体积（cm³/mol）：124.0

  3、 等张比容（90.2K）：298.7

  4、 表面张力（dyne/cm）：33.6

  5、 极化率（10-24cm3）：13.01

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:3

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积46.5

  7.重原子数量:9

  8.表面电荷:0

  9.复杂度:109

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.性状：无色透明液体

  2. 相对密度(20℃/4℃) ：1.0536

  3. 常温折射率（n²⁵）：1.4443

  4.闪点（开杯，℃）：100

  5..凝固点（ºC）：-60

  6..沸点（6661.61Pa,ºC）：77

  7..溶解性：几乎不溶于水。与醇、醚能混溶。易聚合。

生物活性

• 描述: 丙烯酸2-羟丙酯(HPA)对皮肤具有严重刺激性和腐蚀性。2-羟丙基丙烯酸酯(HPA)广泛应用于纤维、粘合剂、橡胶工业、油漆和涂料工业[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Deng K L , et al. Synthesis and characterization of a novel temperature-pH responsive copolymer of 2-hydroxypropyl acrylate and aminoethyl methacrylate hydrochloric salt[J]. eXPRESS Polymer Letters, 2009, 3(2):97-104.

  [2]. Hudson N L , et al. NIOSH skin notation (SK) profile :2-hydroxypropyl acrylate (HPA) [CAS No. 999-61-1]. 2017.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Hydroxypropyl acrylate REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 999-61-1 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin corrosion (Category 1B), H314 Skin sensitisation (Category 1), H317 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC T ToxicR23/24/25 C CorrosiveR34 R43 For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordDanger Hazard statement(s) H301 + H311 + H331Toxic if swallowed, in contact with skin or if inhaled H314Causes severe skin burns and eye damage. H317May cause an allergic skin reaction. Precautionary statement(s) P261Avoid breathing vapours. P280Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310Immediately call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements Other hazards - none SECTION 3: Composition/information on ingredients Substances Molecular Weight: 130,14 g/mol CAS-No.: 999-61-1 EC-No.: 213-663-8 Index-No.: 607-108-00-2 Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration Hydroxypropyl acrylate CAS-No.999-61-1Acute Tox. 3; Skin Corr. 1B;<= 100 % EC-No.213-663-8Skin Sens. 1; H301 + H311 + Index-No.607-108-00-2H331, H314, H317 Hazardous ingredients according to Directive 1999/45/EC ComponentClassificationConcentration Hydroxypropyl acrylate CAS-No.999-61-1T, R23/24/25 - R34 - R43<= 100 % EC-No.213-663-8 Index-No.607-108-00-2 For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon dioxide (CO2) Nature of decomposition products not known. Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information Use water spray to cool unopened containers. SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Specific end use(s) A part from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: liquid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and 77 °C at 7 hPa boiling range g) Flash point89 °C - closed cup h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerLower explosion limit: 1,8 %(V) flammability or explosive limits k) Vapour pressureno data available l) Vapour density4,49 - (Air = 1.0) m) Relative density1,044 g/cm3 n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information Relative vapour density 4,49 - (Air = 1.0) SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid Heat, flames and sparks. Incompatible materials Strong oxidizing agentsStrong oxidizing agents, Strong acids, Nitrates Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity LD50 Oral - rat - 250 mg/kg LD50 Oral - mouse - 1.056 mg/kg LD50 Dermal - rabbit - 167 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation May cause sensitisation by skin contact. Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: Not available Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea SECTION 12: Ecological information Toxicity Toxicity to fishLC50 - Pimephales promelas (fathead minnow) - 3,1 mg/l - 96 h Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects Toxic to aquatic life. no data available SECTION 13: Disposal considerations Waste treatment methods Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 2922IMDG: 2922IATA: 2922 UN proper shipping name ADR/RID: CORROSIVE LIQUID, TOXIC, N.O.S. (Hydroxypropyl acrylate) IMDG: CORROSIVE LIQUID, TOXIC, N.O.S. (Hydroxypropyl acrylate) IATA:Corrosive liquid, toxic, n.o.s. (Hydroxypropyl acrylate) Transport hazard class(es) ADR/RID: 8 (6.1)IMDG: 8 (6.1)IATA: 8 (6.1) Packaging group ADR/RID: IIIMDG: IIIATA: II Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment For this product a chemical safety assessment was not carried out SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. Acute Tox.Acute toxicity H301Toxic if swallowed. H301 + H311 +Toxic if swallowed, in contact with skin or if inhaled H331 H311Toxic in contact with skin. H314Causes severe skin burns and eye damage. H317May cause an allergic skin reaction. H331Toxic if inhaled. Full text of R-phrases referred to under sections 2 and 3 TToxic R23/24/25Toxic by inhalation, in contact with skin and if swallowed. R34Causes burns. R43May cause sensitisation by skin contact. Further information Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AT1925000 CHEMICAL NAME : Acrylic acid, 2-hydroxypropyl ester CAS REGISTRY NUMBER : 999-61-1 BEILSTEIN REFERENCE NO. : 1754331 LAST UPDATED : 199712 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C6-H10-O3 MOLECULAR WEIGHT : 130.16 WISWESSER LINE NOTATION : QY1&1OV1U1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,320,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1056 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 11,125,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 160 uL/kg REFERENCE : AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** REVIEWS *** ACGIH TLV-TWA 2.8 mg/m3 (0.5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.5 ppm (2.8 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (2.7 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-HYDROXYPROPYL ACRYLATE-air:10H TWA 0.5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

安全

• 危害码 (欧洲): F+
• 风险声明 (欧洲): R23/24/25
• 安全声明 (欧洲): S26-S36/37/39-S45
• 危险品运输编码: 2927
• 包装等级: II
• 危险类别: 8

合成路线

2421-07-0 ~% 999-61-1

文献：Journal of Organic Chemistry, , vol. 29, p. 286 - 290

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制备

　丙烯酸与环氧丙烷在催化剂和阻聚剂存在下进行加成反应，生成丙烯酸-2-羟基丙酯粗成品，再经脱气、精馏得成品。丙烯酸由丙烯氧化或丙烯腈水解制得。