338992-12-4

• 常用中文名：N-(4-溴-2-氟苯基)-6-甲氧基-7-(哌啶-4-基甲氧基)喹唑啉-4-胺
• 常用英文名：N-DeMethyl Vandetanib
• CAS号：338992-12-4
• 分子式：C₂₁H₂₂BrFN₄O₂
• 分子量：461.32700
• 发布时间：2018-12-19 10:49:09
• 更新时间：2025-08-25 16:18:27

名称

• 中文名: N-(4-溴-2-氟苯基)-6-甲氧基-7-(哌啶-4-基甲氧基)喹唑啉-4-胺
• 英文名: N-Demethyl Vandetanib
• 英文别名: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine

物化性质

• 分子式: C₂₁H₂₂BrFN₄O₂
• 分子量: 461.32700
• 精确质量: 460.09100
• PSA: 68.30000
• LogP: 5.06380

合成路线

338992-20-4 ~79% 338992-12-4

文献：Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

401811-89-0 367-24-8 ~79% 338992-12-4

文献：ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/13998 A1, 2005 ; Location in patent: Page/Page column 62 ; WO 2005/013998 A1

196603-96-0 ~% 338992-12-4

文献：Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

166815-96-9 ~% 338992-12-4

文献：Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O. Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312

367-24-8 ~% 338992-12-4

文献：Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

162364-72-9 ~% 338992-12-4

文献：Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

768350-54-5 ~% 338992-12-4

文献：Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

上下游产品

上游产品  6
338992-20-4 367-24-8 196603-96-0 166815-96-9
162364-72-9 768350-54-5
下游产品  1
443913-73-3