N-DeMethyl Vandetanib

Modify Date: 2024-02-03 15:09:23

N-DeMethyl Vandetanib Structure
N-DeMethyl Vandetanib structure
Common Name N-DeMethyl Vandetanib
CAS Number 338992-12-4 Molecular Weight 461.32700
Density N/A Boiling Point N/A
Molecular Formula C21H22BrFN4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name N-Demethyl Vandetanib
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C21H22BrFN4O2
Molecular Weight 461.32700
Exact Mass 460.09100
PSA 68.30000
LogP 5.06380

 Synthetic Route

~79%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

~79%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/13998 A1, 2005 ; Location in patent: Page/Page column 62 ; WO 2005/013998 A1

~%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

~%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O. Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312

~%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

~%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

~%

N-DeMethyl Vandetanib Structure

N-DeMethyl Vand...

CAS#:338992-12-4

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

 Synonyms

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine