7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

Modify Date: 2024-01-11 09:23:32

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure
7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine structure
Common Name 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
CAS Number 768350-54-5 Molecular Weight 454.29200
Density 1.489 g/cm3 Boiling Point 541.094ºC at 760 mmHg
Molecular Formula C22H17BrFN3O2 Melting Point N/A
MSDS N/A Flash Point 281.044ºC

 Names

Name N-(4-bromo-2-fluorophenyl)-6-methoxy-7-phenylmethoxyquinazolin-4-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.489 g/cm3
Boiling Point 541.094ºC at 760 mmHg
Molecular Formula C22H17BrFN3O2
Molecular Weight 454.29200
Flash Point 281.044ºC
Exact Mass 453.04900
PSA 56.27000
LogP 5.93560

 Safety Information

HS Code 2933990090

 Synthetic Route

~93%

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup Patent: WO2012/30160 A2, 2012 ;

~%

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup Patent: WO2012/30160 A2, 2012 ;

~%

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup Patent: WO2012/30160 A2, 2012 ;

~%

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Structure

7-(benzyloxy)-N...

CAS#:768350-54-5

Literature: HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup Patent: WO2012/30160 A2, 2012 ;

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

qc-1061
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