439-89-4

• 常用中文名：龙胆碱
• 常用英文名：Gentianine
• CAS号：439-89-4
• 分子式：C₁₀H₉NO₂
• 分子量：175.184
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-06-28 19:31:24
• 更新时间：2024-01-02 18:15:32
• Gentianine 是一种有效的 Swertiamarin 代谢产物,具有抗糖尿病和抗炎作用。

名称

• 中文名: 秦艽甲素
• 英文名: gentianine
• 英文别名: 4-(2-hydroxyethyl)-5-vinylnicotinic acid δ-lactone; 4-<2-Hydroxyaethyl>-5-vinyl-3-pyridin-carboxylic acid lacton; 1H-Pyrano[3,4-c]pyridin-1-one, 5-ethenyl-3,4-dihydro-; 5-VINYLPYRROLIDONE; 4-(2-Hydroxyethyl)-5-vinylnicotinic lactone; 5-Ethenyl-3,4-dihydro-1H-pyrano(3,4-c)pyridin-1-one; Gentianine; 4-(2-Hydroxyethyl)-5-vinylnicotinic Acid d-Lactone; 5-vinylpyrrolidinone; 1H-Pyrano(3,4-c)pyridin-1-one, 3,4-dihydro-5-vinyl-; 2-Pyrrolidinone,5-ethenyl; Erythricine; 5-vinyl-pyrrolidin-2-one; UNII-C2PD310UXB; 5-ethenyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one; 5-Vinyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 386.5±42.0 °C at 760 mmHg
• 熔点: 84-86ºC
• 分子式: C₁₀H₉NO₂
• 分子量: 175.184
• 闪点: 187.6±27.9 °C
• 精确质量: 175.063324
• PSA: 39.19000
• LogP: 1.73
• 外观性状: 粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.604
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: Gentianine 是一种有效的 Swertiamarin 代谢产物,具有抗糖尿病和抗炎作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Vaidya H, et al. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytother Res. 2013 Apr;27(4):624-7.

  [2]. Wenjin C, et al. Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's Complete Adjuvant-Induced Arthritis in Rats. Inflammation. 2017 Aug;40(4):1401-1408.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ1374500 CHEMICAL NAME : 1H-Pyrano(3,4-c)pyridin-1-one, 3,4-dihydro-5-vinyl- CAS REGISTRY NUMBER : 439-89-4 BEILSTEIN REFERENCE NO. : 0137011 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C10-H9-N-O2 MOLECULAR WEIGHT : 175.20 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 276 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,1341,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 7,1,1983 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 25,258,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951

安全

• 危害码 (欧洲): Xi

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