CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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VB4900000
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CHEMICAL NAME :
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Quinoline, 1,2-dihydro-2,2,4-trimethyl-
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CAS REGISTRY NUMBER :
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147-47-7
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C12-H15-N
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MOLECULAR WEIGHT :
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173.28
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WISWESSER LINE NOTATION :
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T66 BM CHJ C1 C1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(1-3),183,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1450 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 31(1-3),183,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12 gm/kg/30D-I
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TOXIC EFFECTS :
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Liver - liver function tests impaired Related to Chronic Data - death
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REFERENCE :
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(2),25,1966
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12500 ug/m3/4H/21W-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 9(8),32,1965
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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18200 mg/kg/13W-I
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TOXIC EFFECTS :
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Liver - changes in liver weight Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-456,1997 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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26 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-456,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2990 No. of Facilities: 237 (estimated) No. of Industries: 9 No. of Occupations: 9 No. of Employees: 2135 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2990 No. of Facilities: 190 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 8109 (estimated) No. of Female Employees: 1529 (estimated)
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