671-95-4

• 常用中文名：氯非那胺
• 常用英文名：clofenamide
• CAS号：671-95-4
• 分子式：C₆H₇ClN₂O₄S₂
• 分子量：270.71
• 相关类别： 原料药 泌尿系统用药 利尿药
• 发布时间：2018-06-02 08:00:00
• 更新时间：2025-08-22 06:52:05
• 氯芬酰胺(Aquedux)是一种碳酸酐酶(CA)抑制剂。氯芬酰胺具有利尿作用[1]。

名称

• 中文名: 氯非那胺
• 英文名: 4-chlorobenzene-1,3-disulfonamide
• 英文别名: Frictan; Eleklin; 4-chloro-benzene-1,3-disulfonic acid diamide; Aponiere; Indigatin; 4-Chlor-benzol-1,3-disulfonamid; Haflutan; Monochlorphenamide; 4-Chlor-benzol-1,3-disulfonsaeure-diamid; Diumide; 1-Chlor-2,4-bis-sulfamoyl-benzol; Clofenamide; Mahi; 4-chloro-benzene-1,3-disulfonamide; Aquedux

物化性质

• 密度: 1.699g/cm3
• 沸点: 551.6ºC at 760 mmHg
• 熔点: 206-207° (Davies); mp 217-219° (Olivier)
• 分子式: C₆H₇ClN₂O₄S₂
• 分子量: 270.71
• 闪点: 287.4ºC
• 精确质量: 269.95400
• PSA: 137.08000
• LogP: 3.19700
• 折射率: 1.627

生物活性

• 描述: 氯芬酰胺(Aquedux)是一种碳酸酐酶(CA)抑制剂。氯芬酰胺具有利尿作用[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ9100000 CHEMICAL NAME : m-Benzenedisulfonamide, 4-chloro- CAS REGISTRY NUMBER : 671-95-4 BEILSTEIN REFERENCE NO. : 2142672 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H7-Cl-N2-O4-S2 MOLECULAR WEIGHT : 270.72 WISWESSER LINE NOTATION : ZSWR BG ESZW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 340 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 661 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

安全

• 海关编码: 2935009090

合成路线

2891-17-0 ~% 671-95-4

文献：Bollettino Chimico Farmaceutico, , vol. 97, p. 451

上下游产品

上游产品  1
2891-17-0
下游产品  0

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%