Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Benzenedisulfonamide,4-chloro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

671-95-4

671-95-4 structure

671-95-4 structure

Name: clofenamide
Chemical Name: 4-chlorobenzene-1,3-disulfonamide
CAS Number: 671-95-4
Molecular Formula: C₆H₇ClN₂O₄S₂
Molecular Weight: 270.71
Catalog: API Urinary system medication Diuretic
Create Date: 2018-06-02 08:00:00
Modify Date: 2024-01-03 08:52:41
Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1].

Name	4-chlorobenzene-1,3-disulfonamide
Synonyms	Frictan Eleklin 4-chloro-benzene-1,3-disulfonic acid diamide Aponiere Indigatin 4-Chlor-benzol-1,3-disulfonamid Haflutan Monochlorphenamide 4-Chlor-benzol-1,3-disulfonsaeure-diamid Diumide 1-Chlor-2,4-bis-sulfamoyl-benzol Clofenamide Mahi 4-chloro-benzene-1,3-disulfonamide Aquedux

Description	Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Metabolic Disease
References	[1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.

Density	1.699g/cm3
Boiling Point	551.6ºC at 760 mmHg
Melting Point	206-207° (Davies); mp 217-219° (Olivier)
Molecular Formula	C₆H₇ClN₂O₄S₂
Molecular Weight	270.71
Flash Point	287.4ºC
Exact Mass	269.95400
PSA	137.08000
LogP	3.19700
Index of Refraction	1.627

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9100000

CHEMICAL NAME :: m-Benzenedisulfonamide, 4-chloro-

CAS REGISTRY NUMBER :: 671-95-4

BEILSTEIN REFERENCE NO. :: 2142672

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-Cl-N2-O4-S2

MOLECULAR WEIGHT :: 270.72

WISWESSER LINE NOTATION :: ZSWR BG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 661 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

HS Code	2935009090

2891-17-0 structure

2891-17-0

~%

671-95-4 structure

671-95-4

Literature: Bollettino Chimico Farmaceutico, , vol. 97, p. 451

Precursor 1
2891-17-0
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%