901230-11-3

• 常用中文名：GNE 9278
• 常用英文名：GNE 9278
• CAS号：901230-11-3
• 分子式：C₂₁H₂₇N₅O₃S
• 分子量：429.536
• 发布时间：2021-01-26 16:15:19
• 更新时间：2024-01-19 19:53:42
• GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology.

名称

• 英文名: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
• 英文别名: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide; Benzenesulfonamide, 4-cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₁H₂₇N₅O₃S
• 分子量: 429.536
• 精确质量: 429.183472
• LogP: 5.24
• 折射率: 1.691