2216753-86-3

• 常用中文名：LYN-1604 盐酸盐
• 常用英文名：LYN-1604 hydrochloride
• CAS号：2216753-86-3
• 分子式：C₃₃H₄₄Cl₃N₃O₂
• 分子量：621.080
• 发布时间：2020-02-11 05:11:14
• 更新时间：2024-04-08 18:53:02
• LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.

名称

• 中文名: LYN-1604 盐酸盐
• 英文名: 1-{4-[2-(2,4-Dichlorophenyl)-2-(2-naphthylmethoxy)ethyl]-1-piperazinyl}-2-(diisobutylamino)ethanone hydrochloride (1:1)
• 英文别名: Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-, hydrochloride (1:1); 1-{4-[2-(2,4-Dichlorophenyl)-2-(2-naphthylmethoxy)ethyl]-1-piperazinyl}-2-(diisobutylamino)ethanone hydrochloride (1:1); MFCD31630830

物化性质

• 分子式: C₃₃H₄₄Cl₃N₃O₂
• 分子量: 621.080
• 精确质量: 619.249939
• 储存条件: 2-8°C，存于惰性气体中

安全

• 危害码 (欧洲): Xn