374683-24-6

• 常用中文名：Kisspeptin-54(human)
• 常用英文名：Kisspeptin-54 (human) trifluoroacetate salt
• CAS号：374683-24-6
• 分子式：C₂₅₈H₄₀₁N₇₉O₇₈
• 分子量：
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 GNRH受体
• 发布时间：2018-07-13 11:00:25
• 更新时间：2024-01-02 08:13:45
• Kisspeptin-54(human) (Metastin(human)) 是一种 Kisspeptin 受体 (KISS1,GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) 可抑制肿瘤转移并刺激促性腺激素分泌。

名称

• 中文名: Metastin(人类)
• 英文名: 4-[[1-[1-[1-[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-[[2-[[2-[[2-[[2-[[1-[[4-amino-1-[[4-amino-1-[2-[[2-[[1-[[2-[[2-[2-[[2-[[2-[[1-[[4-amino-1-[[1-[2-[[2-[2-[[4-amino-1-[[2-[[2-[[1-[[1-[[1-[[4-amino-1-[[1-[[1-[[5-amino-1-[[2-[[1-[2-[[3-amino-1-[[2-[[3-amino-1-[[2-[[3-amino-1-[[2-[[2-[[2-[[1-[[1-[(2-amino-1-benzyl-2-oxo-ethyl)carbamoyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-3-carboxy-propyl]carbamoyl]-4-guanidino-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-methyl-propyl]amino]-1-methyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]-4-oxo-butyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid

物化性质

• 分子式: C₂₅₈H₄₀₁N₇₉O₇₈

生物活性

• 描述: Kisspeptin-54(human) (Metastin(human)) 是一种 Kisspeptin 受体 (KISS1,GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54 受体,其 Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) 可抑制肿瘤转移并刺激促性腺激素分泌。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体
  研究领域 >> 癌症
  研究领域 >> 内分泌
• 靶点:

  Ki: 1.81 nM (Rat GPR54) and 1.45 nM (Human GPR54)[2]

• 参考文献:

  [1]. M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145(9):4073-7.

  [2]. M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6.