232271-19-1

• 常用中文名：(S)-2-(2,6-二氯苯酰胺)-3-(2,6-二甲氧基-[1,1-联苯]-4-基)丙酸
• 常用英文名：TR 14035
• CAS号：232271-19-1
• 分子式：C₂₄H₂₁Cl₂NO₅
• 分子量：474.333
• 相关类别： 信号通路 细胞骨架 Integrin
• 发布时间：2019-01-01 14:15:21
• 更新时间：2024-01-03 05:09:13
• TR-14035是α4β7/α4β1 integrin拮抗剂,IC50为7 nM和87 nM。

名称

• 中文名: (S)-2-(2,6-二氯苯酰胺)-3-(2,6-二甲氧基-[1,1-联苯]-4-基)丙酸
• 英文名: (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acid
• 英文别名: (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-(2',6'-dimethoxybiphenyl-4-yl)propanoic acid (non-preferred name); (2S)-2-[(2,6-Dichlorobenzoyl)amino]-3-(2',6'-dimethoxy-4-biphenylyl)propanoic acid; TR-14035

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 604.0±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₁Cl₂NO₅
• 分子量: 474.333
• 闪点: 319.1±31.5 °C
• 精确质量: 473.079681
• PSA: 84.86000
• LogP: 3.67
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 2-8℃

生物活性

• 描述: TR-14035是α4β7/α4β1 integrin拮抗剂,IC50为7 nM和87 nM。
• 相关类别:
  信号通路 >> 细胞骨架 >> Integrin
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66.

  [2]. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62.

合成路线

232275-99-9 ~84% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

24250-84-8 ~% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

23112-96-1 ~% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

4659-45-4 ~% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

151-10-0 ~% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

232277-15-5 ~% 232271-19-1

文献：Sircar, Ila; Gudmundsson, Kristjan S.; Martin, Richard; Liang, Jimmy; Nomura, Sumihiro; Jayakumar, Honnappa; Teegarden, Bradley R.; Nowlin, Dawn M.; Cardarelli, Pina M.; Mah, Jason R.; Connell, Samuel; Griffith, Ronald C.; Lazarides, Elias Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2051 - 2066

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232275-99-9 24250-84-8 23112-96-1 4659-45-4
151-10-0 232277-15-5
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