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| 中文名 | 索菲布韦杂质27 |
|---|---|
| 英文名 | Sofosbuvir Impurity 27 |
| 英文别名 |
(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester
PSI-7976 (S)((((2R,3R,4R,5R)-5-(2,4-dicarbonyl-3,4-dihydropyrimidine-1(2Η)-yl)-4-fluoro-3-hydroxy-4-tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alanine isopropyl ester (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4- methyltetrahydrofuran-2-yl)methoxy)phenoxyphosphoryl)amino)propanoate (S)-isopropyl 2-((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propionoate (S)-2-{(R)-[(1R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(R)-fluoro-3-hydroxy-4-methyI-tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}propionic acid (S)-isopropyl ester |
| 描述 | PSI-7976是PSI-7977(HY-15005)的同分异构体,能抑制HCV RNA复制,EC50为1.07uM。 |
|---|---|
| 相关类别 | |
| 体外研究 | PSI-7851是两种非对映异构体PSI-7976和PSI-7977的混合物,PSI-7977是HCV复制子测定中HCV RNA复制的更有效的抑制剂。羧酸酯酶1(CES1)优先于PSI-7977水解PSI-7976。动力学数据还表明PSI-7976是CES1比组织蛋白酶A(CatA)更好的底物[1] |
| 参考文献 |
| 分子式 | C22H29FN3O9P |
|---|---|
| 分子量 | 529.45300 |
| 精确质量 | 529.16300 |
| PSA | 167.99000 |
| LogP | 2.04740 |
| 储存条件 | 2-8℃ |