中文名 | 锌原卟啉 |
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英文名 | zinc protoporphyrin |
中文别名 |
原卟啉锌
三水合原卟啉锌 |
英文别名 |
Protoporphyrin IX zinc(II)
EINECS 239-455-7 21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethenyl-3,7,12,17-tetramethyl-, zinc salt (1:1) MFCD00011612 [3,3'-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]zinc zinc 2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethylporphine-21,23-diide Zinc 2,18-bis(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinylporphine-21,23-diide PROTOPORPHYRINATO ZINC zinc,3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid Zinc Protoporphyrin Zinc, [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]- |
描述 | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种竞争性的血红素加氧酶-1 (HO-1) 抑制剂,显着减弱间苯三酚 (PG) 对 H2O2 的保护作用。Zinc Protoporphyrin 是在血红素生物合成期间以痕量形成的正常代谢物,可用作个体孕妇和儿童缺铁的筛查标志物,也用于评估人群铁状态与血红蛋白浓度的组合。 |
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相关类别 | |
参考文献 |
沸点 | 1128.5ºC at 760mmHg |
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分子式 | C34H32N4O4Zn |
分子量 | 626.051 |
闪点 | 636.3ºC |
精确质量 | 624.171509 |
PSA | 109.18000 |
LogP | 3.60970 |
蒸汽压 | 0mmHg at 25°C |
储存条件 | 常温密闭避光,通风干燥 |
稳定性 | 常温常压下稳定 避免的物料: 氧化物 |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:2 3.氢键受体数量:8 4.可旋转化学键数量:8 5.互变异构体数量:无 6.拓扑分子极性表面积102 7.重原子数量:43 8.表面电荷:0 9.复杂度:1010 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
更多 | 1.性状:未确定 2.密度(g/mL,25/4℃):未确定 3.相对蒸汽密度(g/mL,空气=1):未确定 4.熔点(ºC):未确定 5.沸点(ºC,常压):未确定 6.沸点(ºC,5.2kPa):未确定 7.折射率:未确定 8.闪点(ºC):未确定 9.比旋光度(º):未确定 10.自燃点或引燃温度(ºC):未确定 11.蒸气压(kPa,25ºC):未确定 12.饱和蒸气压(kPa,60ºC):未确定 13.燃烧热(KJ/mol):未确定 14.临界温度(ºC):未确定 15.临界压力(KPa):未确定 16.油水(辛醇/水)分配系数的对数值:未确定 17.爆炸上限(%,V/V):未确定 18.爆炸下限(%,V/V):未确定 19.溶解性:未确定 |
Section 1: Product Identification Chemical Name:Zinc protoporphyrin CAS Registry Number:15442-64-5 Formula:(C34H32N4O4)Zn EINECS Number:239-455-7 Chemical Family:metal porphine (porphyrin) complex Synonym:protoporphoryn zinc chelate
Section 2: Composition and Information on Ingredients IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL) Title Compound15442-64-5100%no datano data Section 3: Hazards Identification Emergency Overview:Dust may be irritating to skin, eyes and mucous membranes. May be harmful if swallowed. Primary Routes of Exposure:Ingestion, inhalation Eye Contact:May cause slight to mild irritation of the eyes. Skin Contact:May cause slight to mild irritation of the skin. Inhalation:Some zinc containing dusts irritate the respiratory system and cause metallic taste, dry throat, and chills. Ingestion:If solubilized, Zinc compounds give a harsh metallic taste and may cause nausea and vomiting. Acute Health Affects:May be irritating to skin, eyes and respiratory tract. Inhalation may cause chills and nausea. No serious long-term chronic effects associated with zinc compounds. Prolonged inhalation may cause Chronic Health Affects: laryngitis. Prolonged ingestion may cause constipation. NTP:No IARC:No OSHA:No SECTION 4: First Aid Measures Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need Eye Exposure: assistance in keeping their eye lids open. Get immediate medical attention. Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if Skin Exposure: irritation persists. Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty Inhalation: in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance. Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce Ingestion: vomiting only if directed by medical personnel. SECTION 5: Fire Fighting Measures Flash Point:not applicable Autoignition Temperature:none Explosion Limits:none Extinguishing Medium:carbon dioxide, foam or dry powder If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure Special Fire Fighting Procedures: self- contained breathing apparatus and full protective clothing. Hazardous Combustion andIf involved in a fire this material may emit toxic and corrosive fumes. Decomposion Products: Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards. SECTION 6: Accidental Release Measures Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and Spill and Leak Procedures: swept up. SECTION 7: Handling and Storage Handling and Storage:Store in a cool, dry place in a tightly sealed container. SECTION 8: Exposure Controls and Personal Protection Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory. Skin Protection:Wear protective clothing and gloves. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator Respirator: Protection Program to be in compliance with 29 CFR 1910.134. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. Additional Protection:No additional protection required. SECTION 9: Physical and Chemical Properties Color and Form:purple xtl. Molecular Weight:626.03 Melting Point:no data Boiling Point:no data Vapor Pressure:no data Specific Gravity:no data Odor:none Solubility in Water:Insoluble SECTION 10: Stability and Reactivity Stability:air and moisture stable Hazardous Polymerization:no hazardous polymerization Conditions to Avoid:none Incompatibility:Oxidizing agents Decomposition Products:zinc oxide, nitrogen oxides, carbon monoxide, carbon dioxide and organic fumes. SECTION 11: Toxicological Information RTECS Data:No information available in the RTECS files. Carcinogenic Effects:No data Mutagenic Effects:No data Tetratogenic Effects:No data SECTION 12: Ecological Information Ecological Information:Avoid release to the environment. Very toxic to aquatic organisms. SECTION 13: Disposal Considerations This material and its container must be disposed of as hazardous waste according to local, state and federal Disposal: regulations. SECTION 14: Transportation Shipping Name (CFR):Non-hazardous Hazard Class (CFR):NA Additional Hazard Class (CFR):NA Packaging Group (CFR):NA UN ID Number (CFR):NA Shipping Name (IATA):Non-hazardous Hazard Class (IATA):NA Additional Hazard Class (IATA):NA Packaging Group (IATA):NA UN ID Number (IATA):NA SECTION 15: Regulatory Information TSCA:Listed in the TSCA inventory. SARA (Title 313):Title compound: See category N982 for reporting. Second Ingredient:None SECTION 16 - ADDITIONAL INFORMATION N/A |
生态学数据: 通常对水是不危害的,若无政府许可,勿将材料排入周围环境。
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个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危害码 (欧洲) | Xi |
危险品运输编码 | NONH for all modes of transport |
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