64-02-8

• 常用中文名：EDTA四钠
• 常用英文名：Sodium edetate
• CAS号：64-02-8
• 分子式：C₁₀H₁₂N₂Na₄O₈
• 分子量：380.17
• 相关类别： 有机原料 有机金属类化合物 有机钠
• 发布时间：2018-03-26 08:00:00
• 更新时间：2025-08-20 12:42:26
• 乙二胺四乙酸(EDTA)四钠是一种金属螯合剂(与包括钙在内的金属二价和三价阳离子结合),具有抗凝血和抗高钙血症的活性。乙二胺四乙酸四钠减少了金属离子催化的对蛋白质的氧化损伤,并允许在蛋白质纯化过程中维持还原环境。乙二胺四乙酸四钠也可以减少二硫键的形成[1][2][3]。

名称

• 中文名: 乙二胺四乙酸四钠
• 英文名: EDTA tetrasodium
• 中文别名: EDTA四钠; 乙二胺四乙酸四钠盐四水合物; 維耳新
• 英文别名: Ethylenediaminetetraacetic acid tetrasodium salt; Tetrasodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate; Tetrasodium ethylenediaminetetraacetate; Tetrasodium salt EDTA; MFCD00012460; EINECS 200-573-9; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt; Complexone; TETRASODIUM EDTA; Nullapon; N,N'-Ethylenediaminediacetic acid tetrasodium salt; TETRACEMATE TETRASODIUM; Tetrasodium salt of EDTA; EDTA tetrasodium salt; Tetrasodium edetate; Nervanaid B; EDETIC ACID TETRASODIUM SALT; EDTA sodium; Tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate; Edetate Sodium; EDTA Tetrasodium; Endrate tetrasodium; Sodium edetate; EDTA-4NA

物化性质

• 密度: 6.9 g/cm3
• 沸点: 614.2ºC at 760 mmHg
• 熔点: >300 °C(lit.)
• 分子式: C₁₀H₁₂N₂Na₄O₈
• 分子量: 380.17
• 闪点: 325.2ºC
• 精确质量: 380.018433
• PSA: 167.00000
• 外观性状: 白色奶油色粉末
• 储存条件:

  本品应密封于阴凉干燥处避光保存。

• 稳定性: Stable. Incompatible with strong oxidizing agents.
• 水溶解性: H2O: 0.1 g/mL, clear, colorless
• 计算化学:

  1、 氢键供体数量：0

  2、 氢键受体数量：10

  3、 可旋转化学键数量：7

  4、 拓扑分子极性表面积（TPSA）：167

  5、 重原子数量：24

  6、 表面电荷：0

  7、 复杂度：293

  8、 同位素原子数量：0

  9、 确定原子立构中心数量：0

  10、 不确定原子立构中心数量：0

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：0

  13、 共价键单元数量：5

• 更多:

  1. 性状：白色结晶性粉末

  2. 密度（g/mL,25/4℃）：不确定

  3. 相对蒸汽密度（g/mL,空气=1）：不确定

  4. 熔点（ºC）：>300

  5. 沸点（ºC,常压）：不确定

  6. 沸点（ºC, 5.2kPa）：不确定

  7. 折射率：不确定

  8. 闪点（ºC）：不确定

  9. 比旋光度（º）：不确定

  10. 自燃点或引燃温度（ºC）：不确定

  11. 蒸气压（kPa,25ºC）：不确定

  12. 饱和蒸气压（kPa,60ºC）：不确定

  13. 燃烧热（KJ/mol）：不确定

  14. 临界温度（ºC）：不确定

  15. 临界压力（KPa）：不确定

  16. 油水（辛醇/水）分配系数的对数值：不确定

  17. 爆炸上限（%,V/V）：不确定

  18. 爆炸下限（%,V/V）：不确定

  19. 溶解性：溶于水(H₂O: 0.1g/mL, clear, colorless)和酸，不溶于醇、苯和三氯甲烷

生物活性

• 描述: 乙二胺四乙酸(EDTA)四钠是一种金属螯合剂(与包括钙在内的金属二价和三价阳离子结合),具有抗凝血和抗高钙血症的活性。乙二胺四乙酸四钠减少了金属离子催化的对蛋白质的氧化损伤,并允许在蛋白质纯化过程中维持还原环境。乙二胺四乙酸四钠也可以减少二硫键的形成[1][2][3]。
• 相关类别:
  研究领域 >> 其他
• 参考文献:

  [1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.

  [2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.

  [3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62.

MSDS

Section 1: Product Identification Chemical Name:Ethylenediaminetetraacetic acid, tetrasodium salt tetrahydrate, 99+% CAS Registry Number:64-02-8 Formula:(NaOOCH2)2NCH2CH2N(CH2COONa)2.4H2O EINECS Number:200-573-9 Chemical Family:organic amine Synonym:N,N'-Ethylenediaminediacetic acid tetrasodium salt, Tetrasodium EDTA Section 2: Composition and Information on Ingredients IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL) Title Compound64-02-8100%no datano data Section 3: Hazards Identification Emergency Overview:Irritating to eyes, skin, and respiratory tract. Primary Routes of Exposure:Eyes, Inhalation of dust. Eye Contact:Irritating to eyes. May cause redness and pain. Skin Contact:Mildly irritating to skin. May cause itching and redness. Inhalation:Dust may be irritating to the nose, mucous membranes and respiratory tract. Ingestion:No specific information is available on the physiological effects of ingestion. Acute Health Affects:Irritating to skin, eyes and respiratory tract. Chronic Health Affects:No information available on long-term chronic effects. NTP:No IARC:No OSHA:No SECTION 4: First Aid Measures Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need Eye Exposure: assistance in keeping their eye lids open. Get immediate medical attention. Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if Skin Exposure: irritation persists. Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty Inhalation: in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance. Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce Ingestion: vomiting only if directed by medical personnel. SECTION 5: Fire Fighting Measures Flash Point:no data Autoignition Temperature:none Explosion Limits:none Extinguishing Medium:dry chemical, carbon dioxide, water fog, or foam. If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure Special Fire Fighting Procedures: self-contained breathing apparatus and full protective clothing. Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes. Decomposion Products: Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards. SECTION 6: Accidental Release Measures Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and Spill and Leak Procedures: swept up. SECTION 7: Handling and Storage Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight. SECTION 8: Exposure Controls and Personal Protection Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory. Skin Protection:Wear appropriate chemical resistant gloves and clothing. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator Respirator: Protection Program to be in compliance with 29 CFR 1910.134. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. Additional Protection:No additional protection required. SECTION 9: Physical and Chemical Properties Color and Form:white xtl. Molecular Weight:380.18 (452.23) Melting Point:no data Boiling Point:no data Vapor Pressure:not applicable Specific Gravity:no data Odor:none Solubility in Water:soluble SECTION 10: Stability and Reactivity Stability:air and moisture stable Hazardous Polymerization:no hazardous polymerization Conditions to Avoid:none Incompatibility:oxidizing agents Decomposition Products:carbon monoxide, carbon dioxide, organic fumes, sodium oxide, sodium hydroxide and nitrogen oxides. SECTION 11: Toxicological Information Administration onto the skin (rabbit); Standard Draize test: 500 mg/24H. Administration into the eye (rabbit); RTECS Data:Standard Draize test: 1900 ug. Administration into the eye (rabbit); Standard Draize test: 100 mg/24H. Intraperitoneal (mouse); LD50: 330 mg/kg. Carcinogenic Effects:no data Mutagenic Effects:no data Tetratogenic Effects:no data SECTION 12: Ecological Information Ecological Information:No information available SECTION 13: Disposal Considerations Disposal:Dispose of according to local, state and federal regulations. SECTION 14: Transportation Shipping Name (CFR):Non-hazardous Hazard Class (CFR):NA Additional Hazard Class (CFR):NA Packaging Group (CFR):NA UN ID Number (CFR):NA Shipping Name (IATA):Non-hazardous Hazard Class (IATA):NA Additional Hazard Class (IATA):NA Packaging Group (IATA):NA UN ID Number (IATA):NA SECTION 15: Regulatory Information TSCA:Listed in the TSCA inventory. SARA (Title 313):Title compound not listed. Second Ingredient:none SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：小鼠腹腔LD50：330 mg/kg； CHEMICAL IDENTIFICATION RTECS NUMBER : AH5075000 CHEMICAL NAME : Acetic acid, (ethylenedinitrilo)tetra-, tetrasodium salt CAS REGISTRY NUMBER : 64-02-8 LAST UPDATED : 199710 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C10-H12-N2-O8.4Na MOLECULAR WEIGHT : 380.20 WISWESSER LINE NOTATION : OV1NVO&2N1VO&1VO &-NA- 4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 48,681,1952 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80223 No. of Facilities: 49290 (estimated) No. of Industries: 218 No. of Occupations: 128 No. of Employees: 584676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80223 No. of Facilities: 55714 (estimated) No. of Industries: 293 No. of Occupations: 186 No. of Employees: 1388281 (estimated) No. of Female Employees: 611582 (estimated)

安全

• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/38
• 安全声明 (欧洲): S26-S36/37-S37/39
• WGK德国: 2
• RTECS号: AH5075000
• 海关编码: 2922499990

合成路线

5000-65-7 ~% 64-02-8

文献：Moran, Edmund J.; Fournier, Eric Patent: US2004/6102 A1, 2004 ; US 20040006102 A1

60-00-4 ~% 64-02-8

文献：Esteban, M. F. Gargallo; Serrano, Vilaplana R.; Vilchez, F. Gonzalez Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1987 , vol. 43, # 8 p. 1039 - 1044

773837-37-9 50-00-0 107-15-3 ~% 64-02-8

文献：DOW GLOBAL TECHNOLOGIES LLC.; MOORE, J. W., Jr.; BOOTH, Steven, T.; LEENHOUTS, Ray, O. Patent: WO2011/146582 A2, 2011 ; Location in patent: Page/Page column 10-11 ;

上下游产品

上游产品  5
5000-65-7 60-00-4 773837-37-9 50-00-0
107-15-3
下游产品  1
92-83-1

制备

由乙二胺与氯乙酸反应，或由乙二胺与甲醛、氰化钠反应而得。

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%