63284-71-9

• 常用中文名：氟苯嘧啶醇
• 常用英文名：Nuarimol
• CAS号：63284-71-9
• 分子式：C₁₇H₁₂ClFN₂O
• 分子量：314.741
• 相关类别： 化学农药原药 杀菌剂 其他杀菌剂
• 发布时间：2018-04-15 08:00:00
• 更新时间：2024-01-02 18:39:39
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名称

• 中文名: 氟苯嘧啶醇
• 英文名: nuarimol
• 中文别名: 噻菌醇
• 英文别名: Gauntlet; UNII:ZU7K80U0CY; murox; Caswell No. 419G; trimifruitsc; triminol; el2289; Trimiol; Nuarimol; α-(2-Chlorophenyl)-α-(4-fluorophenyl)-5-pyrimidinemethanol; (2-chlorophenyl)(4-fluorophenyl)pyrimidin-5-ylmethanol; el228; (2-Chlorphenyl)(4-fluorphenyl)pyrimidin-5-ylmethanol; (RS)-2-chloro-4’-fluoro-α-(pyrimidin-5-yl)benzhydryl alcohol; (2-Chlorophenyl)(4-fluorophenyl)5-pyrimidinylmethanol; a-(2-Chlorophenyl)-a-(4-fluorophenyl)-5-pyrimidinemethanol; MFCD00078677; (RS)-2-Chloro-4'-fluoro-a-(pyrimidin-5-yl)benzhydryl alcohol; rac-(R)-(2-chlorophenyl)(4-fluorophenyl)(pyrimidin-5-yl)methanol; (±)-Nuarimol; TRIMIDAL; guantlet; EINECS 264-071-1; 5-Pyrimidinemethanol, α-(2-chlorophenyl)-α-(4-fluorophenyl)-

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 475.2±40.0 °C at 760 mmHg
• 熔点: 126°C
• 分子式: C₁₇H₁₂ClFN₂O
• 分子量: 314.741
• 闪点: 241.2±27.3 °C
• 精确质量: 314.062225
• PSA: 46.01000
• LogP: 2.68
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.623
• 储存条件: 库房低温,通风,干燥
• 分子结构:

  1、 摩尔折射率：82.14

  2、 摩尔体积（m³/mol）：323.8

  3、 等张比容（90.2K）：632.4

  4、 表面张力（dyne/cm）：54.3

  5、 极化率（10^-24cm³）：32.56

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:4

  4.可旋转化学键数量:3

  5.互变异构体数量:无

  6.拓扑分子极性表面积46

  7.重原子数量:22

  8.表面电荷:0

  9.复杂度:359

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：。

  2. 密度（g/mL,25/4℃）：

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：

  5. 沸点（ºC,常压）：

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：。

毒性和生态

毒理学数据: 1 、急性毒性：大鼠（口服）LD50： 1,250 mg/kg 小鼠（口服）LD50： 2,500 mg/kg 狗（口服）LD50： 500 mg/kg 兔子（皮上）LD50： ＞2 mg/kg 鹌鹑（口服）LD50：200 mg/kg 鸟（口服）LD50：200 mg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 CHEMICAL IDENTIFICATION RTECS NUMBER : UV9279700 CHEMICAL NAME : 5-Pyrimidinemethanol, alpha-(2-chlorophenyl)-alpha-(4-fluorophenyl)- CAS REGISTRY NUMBER : 63284-71-9 LAST UPDATED : 199806 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C17-H12-Cl-F-N2-O MOLECULAR WEIGHT : 314.76 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,625,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - domestic DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A303,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 312 mg/kg/5D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,337,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8736 mg/kg/2Y-C TOXIC EFFECTS : Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0545244

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36
• 安全声明 (欧洲): S26
• 危险品运输编码: NONH for all modes of transport
• RTECS号: UV9279700

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