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| 中文名 | 1,4-双(2-羟基乙基)哌嗪 |
|---|---|
| 英文名 | 1,4-Bis(2-hydroxyethyl)piperazine |
| 中文别名 |
1,4-双(2-羟乙基)哌嗪
N,N'-双(2-羟乙基)哌嗪 N,N'-二羟乙基哌嗪 1,4-双(2-羟氧基)对二氮乙环乙烷 |
| 英文别名 |
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanol
MFCD00006157 1,4-Piperazinediethanol N,N′-Bis(2-hydroxyethyl)piperazine EINECS 204-586-0 N,N'-Bis(β-hydroxyethyl)piperazine 2,2'-(1,4-Piperazinediyl)diethanol 2,2'-piperazine-1,4-diyldiethanol 2,2'-(Piperazine-1,4-diyl)diethanol |
| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 305.7±0.0 °C at 760 mmHg |
| 熔点 | 133.5-136 °C(lit.) |
| 分子式 | C8H18N2O2 |
| 分子量 | 174.241 |
| 闪点 | 166.2±22.4 °C |
| 精确质量 | 174.136826 |
| PSA | 46.94000 |
| LogP | -1.14 |
| 外观性状 | 白色结晶粉末 |
| 蒸汽压 | 0.0±1.4 mmHg at 25°C |
| 折射率 | 1.508 |
| 储存条件 | 室温 |
| 分子结构 | 1、 摩尔折射率：47.30 2、 摩尔体积（m3/mol）：158.7 3、 等张比容（90.2K）：407.5 4、 表面张力（dyne/cm）：43.4 5、 极化率（10-24cm3）：18.75 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:-1.3 2.氢键供体数量:2 3.氢键受体数量:4 4.可旋转化学键数量:4 5.互变异构体数量:无 6.拓扑分子极性表面积46.9 7.重原子数量:12 8.表面电荷:0 9.复杂度:99.6 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
Synonym: N,N'-Piperazinediethanol. SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 36/37/38 SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: No information found. SECTION 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. SECTION 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. SECTION 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. SECTION 7 - HANDLING and STORAGE Handling: Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Storage: Store in a cool, dry place. Store in a tightly closed container. SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 122-96-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 215-220 deg C@50mmH Freezing/Melting Point: 134-137 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C8H18N2O2 Molecular Weight: 174.1382 SECTION 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong acids, strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 122-96-3: TL3675000 LD50/LC50: CAS# 122-96-3: Oral, rat: LD50 = 3730 uL/kg; Skin, rabbit: LD50 = >10 mL/kg. Carcinogenicity: N,N'-Bis(2-Hydroxyethyl)piperazine - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. SECTION 12 - ECOLOGICAL INFORMATION SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. SECTION 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 122-96-3: No information available. Canada CAS# 122-96-3 is listed on Canada's DSL List. CAS# 122-96-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 122-96-3 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION MSDS Creation Date: 11/18/1999 Revision #3 Date: 1/28/2004 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. SECTION 16 - ADDITIONAL INFORMATION N/A |
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毒理学数据: 1、皮肤/眼睛刺激：兔子皮肤刺激性实验：10mg/24H 对皮肤有轻微的刺激。 2、急性毒性：大鼠经口LD50：3730mg/kg 兔子皮肤LD50：>10mL/kg
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害码 (欧洲) | Xi |
| 风险声明 (欧洲) | R36/37/38 |
| 安全声明 (欧洲) | S37/39-S26 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | TL3675000 |
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