毒理学数据:
二、毒理学数据:
1、急性毒性:大鼠经口LD50:11200 ug/kg;
大鼠腹腔LD50:4484 ug/kg;
大鼠静脉LD50:4100 ug/kg;
小鼠皮下LD50:32 mg/kg.
生态学数据:
三、生态学数据:
其它有害作用:该物质对环境可能有危害,对水体应给予特别注意。
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
AY3675000
-
CHEMICAL NAME :
-
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-
-
CAS REGISTRY NUMBER :
-
148-82-3
-
BEILSTEIN REFERENCE NO. :
-
2816456
-
LAST UPDATED :
-
199712
-
DATA ITEMS CITED :
-
95
-
MOLECULAR FORMULA :
-
C13-H18-Cl2-N2-O2
-
MOLECULAR WEIGHT :
-
305.23
-
WISWESSER LINE NOTATION :
-
QVYZ1R DN2G2G -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
Rinsed with water
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
700 mg/kg/7D
-
TOXIC EFFECTS :
-
Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
1200 ug/kg/5D-I
-
TOXIC EFFECTS :
-
Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - child
-
DOSE/DURATION :
-
4500 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea Blood - agranulocytosis
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
8140 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea Blood - agranulocytosis
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - infant
-
DOSE/DURATION :
-
28 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Blood - agranulocytosis Blood - thrombocytopenia
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
11200 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
4484 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
4100 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intracerebral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
200 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD10 - Lethal Dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
32 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
20800 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Parenteral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
6 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
29600 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
3 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Blood - normocytic anemia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
14 mg/kg/7D-I
-
TOXIC EFFECTS :
-
Endocrine - changes in spleen weight Immunological Including Allergic - decrease in humoral immune response Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
80 ug/kg/D-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - other changes Blood - lymphoma, including Hodgkin's disease
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
57 ug/kg/D-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - other changes Blood - lymphoma, including Hodgkin's disease
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
26 mg/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
70 mg/kg/26W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
58 mg/kg/9W-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
60 mg/kg/26W-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
15 mg/kg/6W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
66 mg/kg/4Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
34 mg/kg/2Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
12 mg/kg/3Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
23 mg/kg/2Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
17 mg/kg/4Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
3750 ug/kg
-
SEX/DURATION :
-
female 25 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - menstrual cycle changes or disorders
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
DOSE :
-
8800 ug/kg
-
SEX/DURATION :
-
female 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - other effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
DOSE :
-
5946 ug/kg
-
SEX/DURATION :
-
female 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - menstrual cycle changes or disorders
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
Sex chromosome loss and nondisjunction
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
DNA damage
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
DNA inhibition
-
TYPE OF TEST :
-
Sister chromatid exchange
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Heritable translocation test
MUTATION DATA
-
TYPE OF TEST :
-
DNA damage
-
TEST SYSTEM :
-
Mammal - species unspecified Lymphocyte
-
DOSE/DURATION :
-
2500 nmol/L
-
REFERENCE :
-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,235,1996 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,239,1987 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,167,1975 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,239,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4742 No. of Facilities: 140 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2418 (estimated) No. of Female Employees: 974 (estimated)
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