194222-05-4

• 常用中文名：3-exo-3-羟基-8-氮杂双环[3.2.1]辛烷-8-甲酸叔丁酯
• 常用英文名：tert-butyl exo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS号：194222-05-4
• 分子式：C₁₂H₂₁NO₃
• 分子量：227.30000
• 发布时间：2018-12-24 10:19:50
• 更新时间：2025-08-25 14:48:23

名称

• 中文名: (1R,3s,5S)-叔丁基3-羟基-8-氮杂双环[3.2.1]辛烷-8-羧酸
• 英文名: tert-butyl (1S,5R)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• 英文别名: MFCD16294321

物化性质

• 熔点: 139.5-140.8 °C
• 分子式: C₁₂H₂₁NO₃
• 分子量: 227.30000
• 精确质量: 227.15200
• PSA: 49.77000
• LogP: 1.84710
• 外观性状: 白色至黄色固体
• 储存条件: 2-8°C，密封，干燥

安全

• 危害码 (欧洲): T+

合成路线

937734-25-3 ~97% 194222-05-4

文献：Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven Patent: US2007/123525 A1, 2007 ; Location in patent: Page/Page column 20 ; US 20070123525 A1

652148-00-0 34619-03-9 ~37% 194222-05-4 143557-91-9

文献：PFIZER PRODUCTS INC. Patent: WO2004/9588 A1, 2004 ; Location in patent: Page 49 ; WO 2004/009588 A1

185099-67-6 ~24% 194222-05-4 143557-91-9

文献：GRUeNENTHAL GMBH; MERLA, Beatrix; OBERBOeRSCH, Stefan; REICH, Melanie; SCHUNK, Stefan; JOSTOCK, Ruth; HEES, Sabine; ENGELS, Michael; GERMANN, Tieno; BIJSTERVELD, Edward Patent: WO2010/99938 A1, 2010 ; Location in patent: Page/Page column 106 ;

185099-67-6 ~% 194222-05-4

文献：Banyu Pharmaceutical Co., Ltd. Patent: EP2204368 A1, 2010 ; Location in patent: Page/Page column 16 ;

24424-99-5 7087-68-5 ~% 194222-05-4

文献：Schering Corporation Patent: US5968929 A1, 1999 ;

24424-99-5 ~% 194222-05-4 143557-91-9

文献：CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD. Patent: US2012/53180 A1, 2012 ; US 20120053180 A1

28957-72-4 ~% 194222-05-4 143557-91-9

文献：CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD. Patent: US2012/53180 A1, 2012 ; US 20120053180 A1

143557-91-9 ~% 194222-05-4

文献：Xia, Yan; Chackalamannil, Samuel; Greenlee, William J.; Jayne, Charles; Neustadt, Bernard; Stamford, Andrew; Vaccaro, Henry; Xu, Xiaoying; Baker, Hana; O'Neill, Kim; Woods, Morgan; Hawes, Brian; Kowalski, Tim Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3290 - 3296

24424-99-5 ~% 194222-05-4

文献：DAINIPPON SUMITOMO PHARMA CO., LTD. Patent: US2012/225876 A1, 2012 ;