521-18-6

• 常用中文名：雄诺龙
• 常用英文名：Stanolone
• CAS号：521-18-6
• 分子式：C₁₉H₃₀O₂
• 分子量：290.440
• 相关类别： 分析化学 标准品 标准物质
• 发布时间：2018-06-01 08:00:00
• 更新时间：2024-01-02 19:09:47
• 雄激素类药

名称

• 中文名: 5α-二氢睾酮
• 英文名: 17β-hydroxy-5α-androstan-3-one
• 中文别名: 雄诺龙
• 英文别名: Stanolone; EINECS 208-307-3; Anaboleen; 17β-Hydroxy-5α-androstane-3-one; Androlone; dihydrotestosterone; Anabolex; (5a,17b)-17-Hydroxyandrostan-3-one; 5α-Dihydrotestosterone; Stanorone; 5α dihydrotestosterone; Androstanolone; DHT; [14C]-Dihydrotestosterone; Androstan-3-one, 17-hydroxy-, (5α,17β)-; 5α-Androstan-3-one, 17β-hydroxy-; [3H]-Dihydrotestosterone; 17beta-hydroxy-5alpha-androstan-3-one; Andractim; 17β-hydroxy-5α-androstan-3-one; Androstan-17b-ol-3-one; Stanaprol; 4-dihydrotestosterone; Neodrol; (5α,17β)-17-Hydroxyandrostan-3-one; 5a-Dihydrotestosterone; Protona; Stanolon; Anaprotin; MFCD00003667

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 413.1±38.0 °C at 760 mmHg
• 熔点: 178-183 °C
• 分子式: C₁₉H₃₀O₂
• 分子量: 290.440
• 闪点: 176.4±19.4 °C
• 精确质量: 290.224579
• PSA: 37.30000
• LogP: 3.75
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.536
• 储存条件:

  本品应密封于阴凉干燥处保存。

• 稳定性:

  按规格使用和贮存，不会发生分解，避免与氧化物接触

• 分子结构:

  1、 摩尔折射率：83.49

  2、 摩尔体积（m³/mol）：267.6

  3、 等张比容（90.2K）：677.7

  4、 表面张力（dyne/cm）：41.1

  5、 极化率（10^-24cm³）：33.10

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：3.7

  2、 氢键供体数量：1

  3、 氢键受体数量：2

  4、 可旋转化学键数量：0

  5、 互变异构体数量：3

  6、 拓扑分子极性表面积（TPSA）：37.3

  7、 重原子数量：21

  8、 表面电荷：0

  9、 复杂度：459

  10、 同位素原子数量：0

  11、 确定原子立构中心数量：7

  12、 不确定原子立构中心数量：0

  13、 确定化学键立构中心数量：0

  14、 不确定化学键立构中心数量：0

  15、 共价键单元数量：1

• 更多:

  1. 性状：结晶。一种促蛋白质合成的甾类化合物。

  2. 密度（g/mL,25/4℃）： 未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：181

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：－32.4°（乙醇中）

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于丙酮、乙醚、乙醇、乙酸乙酯，几乎不溶于水。

毒性和生态

生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : BV8052000 CHEMICAL NAME : 5-alpha-Androstan-3-one, 17-beta-hydroxy- CAS REGISTRY NUMBER : 521-18-6 LAST UPDATED : 199206 DATA ITEMS CITED : 19 MOLECULAR FORMULA : C19-H30-O2 MOLECULAR WEIGHT : 290.49 WISWESSER LINE NOTATION : L E5 B666 OVTJ A1 E1 FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 17500 ug/kg SEX/DURATION : female 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 160 mg/kg SEX/DURATION : female 14-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1400 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 700 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 80 mg/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 2500 ug/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 168 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant DOSE : 24 mg/kg SEX/DURATION : male 42 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 150 mg/kg SEX/DURATION : female 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 40 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 40 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 gm/kg SEX/DURATION : female 14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - skin and skin appendages TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 24 mg/kg SEX/DURATION : female 3 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 200 ug/kg SEX/DURATION : male 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 14 mg/kg SEX/DURATION : male 70 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant DOSE : 3420 ug/kg SEX/DURATION : male 90 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 30 mg/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 1500 ug/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) MUTATION DATA TEST SYSTEM : Non-mammalian species DOSE/DURATION : 12 mg/8W (Intermittent) REFERENCE : JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year: 205,403,1978

安全

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P280-P302 + P352 + P312-P304 + P340 + P312-P370 + P378-P403 + P235
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R61
• 安全声明 (欧洲): S53-S36/37/39-S45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK德国: 3
• RTECS号: BV8052000
• 包装等级: II
• 危险类别: 6.1

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