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没食子酸甲酯

没食子酸甲酯用途

Methyl gallate是具有抗氧化,抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。

没食子酸甲酯名称

[ CAS 号 ]:
99-24-1

[ 中文名 ]:
没食子酸甲酯

[ 英文名 ]:
Methyl gallate

[中文别名 ]:

[英文别名 ]:

Methyl gallate
MFCD00002194
3,4,5-Trihydroxybenzoic acid methyl ester
Benzoic acid, 3,4,5-trihydroxy-, methyl ester
Methyl 3,4,5-trihydroxybenzoate
EINECS 202-741-7

没食子酸甲酯生物活性

[ 描述 ]:

Methyl gallate是具有抗氧化,抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 心血管疾病

研究领域 >> 癌症

研究领域 >> 感染

天然产物 >> 酚类

[ 靶点 ]

Bacterial[1]

[体外研究]

通过低剂量的没食子酸甲酯(MIC = 1mg/mL)完全抑制A.viscosus的生长。变形链球菌和。 sobrinus显示对没食子酸甲酯(MIC = 2-4 mg/mL)的中度敏感性,而乳杆菌属的生长。在较高浓度(MIC = 8 mg/mL)[1]时完全被抑制。浓度为100mM的没食子酸甲酯可以减轻暴露于短期H2O2处理的细胞的脂质过氧化。此外,没食子酸甲酯处理的细胞可以在H2O2(8.0 mM)暴露3小时后阻止细胞内谷胱甘肽(GSH)的消耗[2]。没食子酸甲酯抑制Treg细胞对效应CD4 + T细胞的抑制作用和Treg向肿瘤环境的迁移。此外,叉头箱P3(Foxp3)的表达也被没食子酸甲酯显着降低[3]。

[细胞实验]

将KB细胞（人口上皮细胞系）用没食子酸甲酯（1-8mg / mL）处理24小时。通过改良的MTT测定法评估没食子酸甲酯的细胞毒性[1]。

[参考文献]

[1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50.

[2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50.

[3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705.

[相关活性小分子]

没食子酸甲酯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
450.1±40.0 °C at 760 mmHg

[ 熔点 ]:
201-204 °C

[ 分子式 ]:
C₈H₈O₅

[ 分子量 ]:
184.146

[ 闪点 ]:
190.8±20.8 °C

[ 精确质量 ]:
184.037170

[ PSA ]:
86.99000

[ LogP ]:
1.54

[ 外观性状 ]:
白色至略米色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.631

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

没食子酸甲酯MSDS

详细MSDS(安全技术说明书)

没食子酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW8000000

CHEMICAL NAME :: Gallic acid, methyl ester

CAS REGISTRY NUMBER :: 99-24-1

BEILSTEIN REFERENCE NO. :: 2113180

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-O5

MOLECULAR WEIGHT :: 184.16

WISWESSER LINE NOTATION :: QVR CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 784 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

没食子酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R43

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LW8000000

[ 海关编码 ]:
2918290000

没食子酸甲酯合成路线

详细合成路线

没食子酸甲酯上下游产品

没食子酸甲酯上游产品

没食子酸甲酯下游产品

没食子酸甲酯制备

用没食子酸与甲醇在硫酸催化下酯化制得。

没食子酸甲酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

没食子酸甲酯文献

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice.

PLoS ONE 10 , e0128221, (2015)

Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological...

Characterization and storage stability of the extract of Thai mango (Mangifera indica Linn. Cultivar Chok-Anan) seed kernels.

J. Food Sci. Technol. 51(8) , 1453-62, (2014)

Qualitative analysis of hydrolysable extract from mango (Mangifera indica Linn. cultivar Chok-Anan) seed kernel was performed by means of reversed phase high-performance liquid chromatography coupled ...

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