3-羟基苯甲酸

3-羟基苯甲酸用途

【用途一】
用作杀菌剂、防腐剂、增塑剂及医药的中间体，也可用来合成偶氮染料
【用途二】
用作偶氮染料中间体，也用于有机合成
【用途三】
间羟基苯甲酸是除草剂氟磺胺草醚的中间体。
【用途四】
本品可用物杀菌剂，防腐剂，增塑剂及医药中间体。亦可用以偶氮染料的合成。
【用途五】
用作杀菌剂、防腐剂、增塑剂及医药的中间体。也用来合成偶染料。
【用途六】
用作杀菌剂、涂料、防腐剂、离子交换剂、增塑剂及医药的中间体，也可用来合成偶氮染料等。

3-羟基苯甲酸名称

[ CAS 号 ]:
99-06-9

[ 中文名 ]:
间羟基苯甲酸

[ 英文名 ]:
3-Hydroxybenzoicacid

[中文别名 ]:

[英文别名 ]:

3-Hydroxybenzoic acid
m-salicylicacid
3-hydroxy-benzoicaci
m-hydroxy-benzoicaci
MFCD00002506
Benzoic acid, 3-hydroxy-
RARECHEM AL BO 0049
m-Hba
3-Carboxyphenol
m-hydroxylbenzoic acid

3-羟基苯甲酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
346.1±25.0 °C at 760 mmHg

[ 熔点 ]:
201 °C

[ 分子式 ]:
C₇H₆O₃

[ 分子量 ]:
138.121

[ 闪点 ]:
177.3±19.7 °C

[ 精确质量 ]:
138.031693

[ PSA ]:
57.53000

[ LogP ]:
1.50

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.616

[ 储存条件 ]:
室温

[ 水溶解性 ]:
slightly soluble

3-羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

3-羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH1924980

CHEMICAL NAME :: Benzoic acid, m-hydroxy-

CAS REGISTRY NUMBER :: 99-06-9

BEILSTEIN REFERENCE NO. :: 0508160

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H6-O3

MOLECULAR WEIGHT :: 138.13

WISWESSER LINE NOTATION :: QVR CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,53,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 19,483,1946 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 38,209,1982

3-羟基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DH1924980

[ 海关编码 ]:
2918290000

3-羟基苯甲酸合成路线

详细合成路线

3-羟基苯甲酸上下游产品

3-羟基苯甲酸上游产品

3-羟基苯甲酸下游产品

3-羟基苯甲酸制备

1.其制备方法过去是以苯甲酸为原料，用硫酸进行磺化，再进一步碱熔，然后酸化得成品。该方法磺化、碱熔腐蚀性强，温度高，操作环境差，现已不用该工艺，而用间甲酚为原料，先与乙酸酐或乙酰氯对羧基进行保护成为乙酸酯，再进一步在催化剂存在下进行空气氧化生成相应的羧酸，再水解得到成品。反应式如下：

2.苯甲酸磺化碱熔法。

3.将稀硫酸加热至160℃，慢慢倒入间氨基苯甲酸重氮液，加完后加热煮沸到没有气泡。冷却过滤得粗品。以水重结晶即得成品。

4. 烟草：FC，54。

3-羟基苯甲酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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