Environmental Science and Pollution Research International 2014-01-01

Degradation of anti-inflammatory drug ketoprofen by electro-oxidation: comparison of electro-Fenton and anodic oxidation processes.

Ling Feng, Nihal Oturan, Eric D van Hullebusch, Giovanni Esposito, Mehmet A Oturan

文献索引:Environ. Sci. Pollut. Res. Int. 21(14) , 8406-16, (2014)



The electrochemical degradation of the nonsteroidal anti-inflammatory drug ketoprofen in tap water has been studied using electro-Fenton (EF) and anodic oxidation (AO) processes with platinium (Pt) and boron-doped diamond (BDD) anodes and carbon felt cathode. Fast degradation of the parent drug molecule and its degradation intermediates leading to complete mineralization was achieved by BDD/carbon felt, Pt/carbon felt, and AO with BDD anode. The obtained results showed that oxidative degradation rate of ketoprofen and mineralization of its aqueous solution increased by increasing applied current. Degradation kinetics fitted well to a pseudo-first-order reaction. Absolute rate constant of the oxidation of ketoprofen by electrochemically generated hydroxyl radicals was determined to be (2.8 ± 0.1) × 10(9) M(-1) s(-1) by using competition kinetic method. Several reaction intermediates such as 3-hydroxybenzoic acid, pyrogallol, catechol, benzophenone, benzoic acid, and hydroquinone were identified by high-performance liquid chromatography (HPLC) analyses. The formation, identification, and evolution of short-chain aliphatic carboxylic acids like formic, acetic, oxalic, glycolic, and glyoxylic acids were monitored with ion exclusion chromatography. Based on the identified aromatic/cyclic intermediates and carboxylic acids as end products before mineralization, a plausible mineralization pathway was proposed. The evolution of the toxicity during treatments was also monitored using Microtox method, showing a faster detoxification with higher applied current values.


结构式 名称/CAS号 全部文献
硫酸 结构式 硫酸
二苯甲酮 结构式 二苯甲酮
氢氧化钠 结构式 氢氧化钠
邻苯三酚 结构式 邻苯三酚
甲醇 结构式 甲醇
3-羟基苯甲酸 结构式 3-羟基苯甲酸
苯酚 结构式 苯酚
苯甲酸 结构式 苯甲酸
3-乙基-2,4-戊二酮 结构式 3-乙基-2,4-戊二酮
对苯二酚 结构式 对苯二酚