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S-()-Eticlopride 盐酸盐

S-()-Eticlopride 盐酸盐用途

盐酸艾屈哌啶是一种选择性多巴胺D2样受体拮抗剂,对多巴胺D2、α1肾上腺素能、α2肾上腺素能、5HT1、5HT2受体具有高度亲和力,Kis分别为0.09、112、699、6220和830nm。抗精神病药[1]。

S-()-Eticlopride 盐酸盐名称

[ CAS 号 ]:
97612-24-3

[ 中文名 ]:
S-(-)-依替必利盐酸盐

[ 英文名 ]:
FLB 131

[英文别名 ]:

MFCD00055132

S-()-Eticlopride 盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

D2 Receptor:0.09 nM (Ki)

[参考文献]

[1]. Jennifer L Martelle, et al. A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. CNS Neurosci Ther. Fall 2008;14(3):248-62.

S-()-Eticlopride 盐酸盐物理化学性质

[ 熔点 ]:
144 - 146 °C

[ 分子式 ]:
C₁₇H₂₆Cl₂N₂O₃

[ 分子量 ]:
377.306

[ 精确质量 ]:
376.132050

[ 外观性状 ]:
灰白色或米色固体

[ 储存条件 ]:
室温

S-()-Eticlopride 盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CV2450000

S-()-Eticlopride 盐酸盐文献

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

J. Neurosci. 31 , 5512-25, (2011)

An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,...

Dopamine D2 receptors are involved in the regulation of Fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo.

J. Neurosci. Res. 94 , 329-38, (2016)

Fyn, a major Src family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member ...

Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain.

Eur. J. Pharmacol. 111 , 191-199, (1985)

The substituted benzamide compound eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxysalicylamide hydrochloride (FLB 131), has been shown to selectively block dopamine...

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