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DL-丙交酯

DL-丙交酯用途

主要用于医药方面。

DL-丙交酯名称

[ CAS 号 ]:
95-96-5

[ 中文名 ]:
3,6-二甲基-1,4-二氧杂环己烷-2,5-二酮

[ 英文名 ]:
lactide

[中文别名 ]:

[英文别名 ]:

L-(-)-Dilactide
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione
L-(-)-Lactide
3,6-Dimethyl-1,4-dioxane-2,5-dione
1,4-Dioxane-2,5-dione, 3,6-dimethyl-
EINECS 202-468-3
UNII:7EH08MWO6M
L-Lactide
MFCD00011685
DL-Lactide

DL-丙交酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
285.5±15.0 °C at 760 mmHg

[ 熔点 ]:
116-119ºC

[ 分子式 ]:
C₆H₈O₄

[ 分子量 ]:
144.125

[ 闪点 ]:
150.6±18.8 °C

[ 精确质量 ]:
144.042252

[ PSA ]:
52.60000

[ LogP ]:
-1.45

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.429

[ 储存条件 ]:
2~8℃

DL-丙交酯MSDS

DL-丙交酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JH1100000

CHEMICAL NAME :: 1,4-Dioxane-2,5-dione, 3,6-dimethyl-

CAS REGISTRY NUMBER :: 95-96-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H8-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 35 gm/kg/2W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),274,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9100 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),274,1997

DL-丙交酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

[ RTECS号 ]:
JH1100000

[ 海关编码 ]:
2934999090

DL-丙交酯合成路线

DL-丙交酯上下游产品

DL-丙交酯上游产品

DL-丙交酯下游产品

DL-丙交酯制备

以D ,L - 乳酸为原料,在催化剂存在下通过脱水环化合成D ,L - 丙交酯。用重结晶法对粗产物进行纯化,制备出高产率、高纯度的D ,L - 丙交酯。

DL-丙交酯海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

DL-丙交酯文献

Magnesium amino-bis(phenolato) complexes for the ring-opening polymerization of rac-lactide.

Dalton Trans. 44 , 12365-75, (2015)

Magnesium compounds of tetradentate amino-bis(phenolato) ligands, Mg[L1] (1) and Mg[L2] (2) (where [L1] = 2-pyridyl-N,N-bis(2-methylene-4-methoxy-6-tert-butylphenolato), and [L2] = dimethylaminoethyla...

The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release.

J. Pharm. Sci. 104(4) , 1451-60, (2015)

For ternary solid dispersions, it is indispensable to characterize their structure, phase behavior, and the spatial distribution of the dispersed drug as this might influence the release profile and/o...

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.

ACS Nano 9 , 9912-21, (2015)

The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shel...

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