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烟酸苄酯

烟酸苄酯用途

烟酸苄酯是一种血管扩张剂,用作引起充血的活性成分[1][2]。

烟酸苄酯名称

[ CAS 号 ]:
94-44-0

[ 中文名 ]:
烟酸苄酯

[ 英文名 ]:
Benzyl nicotinate (JAN)

[中文别名 ]:

[英文别名 ]:

Pyridine-3-carboxylic Acid Benzyl Ester
Pyridine-b-carboxylic Acid Benzyl Ester
Benzyl nicotinate
Benzyl nicotinate (JAN)
benzyl pyridine-3-carboxylate
MFCD00023584
3-Pyridinecarboxylic acid, phenylmethyl ester
nicotinic acid benzyl ester
3-Pyridinecarboxylic acid phenylmethyl ester
EINECS 202-332-3

烟酸苄酯生物活性

[ 描述 ]:

烟酸苄酯是一种血管扩张剂,用作引起充血的活性成分[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Erjavec V, et al. In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry. Int J Pharm. 2006;307(1):1-8.

[2]. Petelin M, et al. In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetry. Int J Pharm. 2004;270(1-2):83-91.

烟酸苄酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
334.1±17.0 °C at 760 mmHg

[ 熔点 ]:
24 °C(lit.)

[ 分子式 ]:
C₁₃H₁₁NO₂

[ 分子量 ]:
213.232

[ 闪点 ]:
155.8±20.9 °C

[ 精确质量 ]:
213.078979

[ PSA ]:
39.19000

[ LogP ]:
2.65

[ 外观性状 ]:
黄色液体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
2~8℃

烟酸苄酯MSDS

烟酸苄酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT0850000

CHEMICAL NAME :: Nicotinic acid, benzyl ester

CAS REGISTRY NUMBER :: 94-44-0

BEILSTEIN REFERENCE NO. :: 0159169

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H11-N-O2

MOLECULAR WEIGHT :: 213.25

WISWESSER LINE NOTATION :: T6NJ CVO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 12,79,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 11,242,1956

烟酸苄酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QT0850000

[ 海关编码 ]:
2933399090

烟酸苄酯合成路线

烟酸苄酯上下游产品

烟酸苄酯上游产品

烟酸苄酯下游产品

烟酸苄酯海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

烟酸苄酯文献

Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled study.

Int. J. Cosmet. Sci. 36(5) , 412-8, (2014)

The mammalian skin is a barrier that effectively separates the water-rich interior of the body from the normally dryer exterior. Changes in the external conditions, for example ambient humidity, have ...

[On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].

Derm. Beruf Umwelt. 29(6) , 161-7, (1981)

Three radioactively marked substances (on the basis of a carbopol gel, 80% water - isopropanol) were analyzed comparatively in regard to the penetration of ethyleneglycolmonosalicylate and benzylnicot...

Kinetics of blood flow after topical application of benzyl nicotinate on different anatomic sites.

Arch. Dermatol. Res. 298(6) , 291-300, (2006)

Cutaneous characteristics, e.g., thickness of the SC and density of follicles, affect the penetration of topically applied substances. In the present study, the penetration of benzyl nicotinate, causi...

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