<生产厂家价格>

O-去甲文拉法辛

O-去甲文拉法辛用途

Desvenlafaxine是5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki为40.2 nM和558.4 nM。

O-去甲文拉法辛名称

[ CAS 号 ]:
93413-62-8

[ 中文名 ]:
O-去甲文拉法辛

[ 英文名 ]:
O-Desmethylvenlafaxine

[中文别名 ]:

[英文别名 ]:

desvenlafaxine
O-Desmethylvenlafaxine
L6TJ AYR DQ&1N1&1 AQ

O-去甲文拉法辛生物活性

[ 描述 ]:

Desvenlafaxine是5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki为40.2 nM和558.4 nM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65.

[2]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42(10): p. 1439-46.

[相关活性小分子]

O-去甲文拉法辛物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
403.8±25.0 °C at 760 mmHg

[ 熔点 ]:
208-213ºC

[ 分子式 ]:
C₁₆H₂₅NO₂

[ 分子量 ]:
263.375

[ 闪点 ]:
193.2±21.8 °C

[ 精确质量 ]:
263.188538

[ PSA ]:
43.70000

[ LogP ]:
2.26

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
-20°C Freezer

O-去甲文拉法辛MSDS

O-去甲文拉法辛安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T,Xi

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25-36

[ 安全声明 (欧洲) ]:
7-16-36/37-45-26

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS号 ]:
GV8872620

[ 海关编码 ]:
2922509090

O-去甲文拉法辛合成路线

O-去甲文拉法辛上下游产品

O-去甲文拉法辛上游产品

O-去甲文拉法辛下游产品

O-去甲文拉法辛海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

O-去甲文拉法辛文献

Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015)

Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix c...

Hollow-fiber liquid-phase microextraction and chiral LC-MS/MS analysis of venlafaxine and its metabolites in plasma.

Bioanalysis 5(6) , 721-30, (2013)

An enantioselective analytical method was developed and validated for determination of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in plasma samples. The method e...

A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine.

Forensic Sci. Int. 226(1-3) , e26-31, (2013)

We present a fatal drug poisoning case involving venlafaxine (VEN). The deceased took his medication regularly (including 150 mg VEN twice daily), and nothing in the case or autopsy findings pointed t...

更多文献

O-去甲文拉法辛

O-去甲文拉法辛用途

O-去甲文拉法辛名称

O-去甲文拉法辛生物活性

O-去甲文拉法辛物理化学性质

O-去甲文拉法辛MSDS

详细MSDS(安全技术说明书)

O-去甲文拉法辛安全信息

O-去甲文拉法辛合成路线

详细合成路线

O-去甲文拉法辛上下游产品

O-去甲文拉法辛上游产品

O-去甲文拉法辛下游产品

O-去甲文拉法辛海关

O-去甲文拉法辛文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

相关化合物