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N-苯基邻氨基苯甲酸(钒试剂)

N-苯基邻氨基苯甲酸(钒试剂)用途

Fenamic acid 是一种氯通道阻滞剂。

N-苯基邻氨基苯甲酸(钒试剂)名称

[ CAS 号 ]:
91-40-7

[ 中文名 ]:
N-苯基邻氨基苯甲酸

[ 英文名 ]:
N-Phenylanthranilic acid

[中文别名 ]:

[英文别名 ]:

N-Phenylanthranilic acid
EINECS 202-066-8
FENAMIC ACID
Phenylanthranillic acid
Benzoic acid, 2-(phenylamino)-
2-Phenylamino-benzoic acid
MFCD00002421
-Phenylanthranilic Acid
2-Anilinobenzoic acid

N-苯基邻氨基苯甲酸(钒试剂)生物活性

[ 描述 ]:

Fenamic acid 是一种氯通道阻滞剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 氯离子通道

研究领域 >> 炎症/免疫

[ 靶点 ]

Chloride Channel[1]

[参考文献]

[1]. Betton GR, et, al. Biomarkers of collecting duct injury in Han-Wistar and Sprague-Dawley rats treated with N-phenylanthranilic Acid. Toxicol Pathol. 2012 Jun;40(4):682-94.

N-苯基邻氨基苯甲酸(钒试剂)物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
385.2±25.0 °C at 760 mmHg

[ 熔点 ]:
182-185 °C(lit.)

[ 分子式 ]:
C₁₃H₁₁NO₂

[ 分子量 ]:
213.232

[ 闪点 ]:
186.7±23.2 °C

[ 精确质量 ]:
213.078979

[ PSA ]:
49.33000

[ LogP ]:
4.41

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

N-苯基邻氨基苯甲酸(钒试剂)MSDS

N-苯基邻氨基苯甲酸(钒试剂)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB3730000

CHEMICAL NAME :: Anthranilic acid, N-phenyl-

CAS REGISTRY NUMBER :: 91-40-7

BEILSTEIN REFERENCE NO. :: 1456607

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H11-N-O2

MOLECULAR WEIGHT :: 213.25

WISWESSER LINE NOTATION :: QVR BMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,105,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1392,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6442 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

N-苯基邻氨基苯甲酸(钒试剂)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB3730000

[ 海关编码 ]:
29224995

N-苯基邻氨基苯甲酸(钒试剂)合成路线

N-苯基邻氨基苯甲酸(钒试剂)上下游产品

N-苯基邻氨基苯甲酸(钒试剂)上游产品

N-苯基邻氨基苯甲酸(钒试剂)下游产品

N-苯基邻氨基苯甲酸(钒试剂)制备

将2g邻氨基苯甲酸、3.2g溴苯、2g碳酸钾、0.1g铅粉和12mg硝基苯混合，加热回流3h。用水蒸气蒸除硝基和未反应的溴苯，冷却后过滤，用盐酸使滤液呈酸性，得N-苯基邻氨基苯甲酸粗品。粗品经苯重结晶，是3g成品。

N-苯基邻氨基苯甲酸(钒试剂)海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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