苄噻嗪
苄噻嗪用途
苄噻嗪名称
[ CAS 号 ]:
91-33-8
[ 中文名 ]:
苄噻嗪
[ 英文名 ]:
Benzthiazide
[中文别名 ]:
[英文别名 ]:
- Lemazide
- benzotiazide
- Exna
- Benzothiazide
- Benzthiazidum
- EINECS 202-061-0
- MFCD00078969
- Freeuril
- Aquatag
- Dihydrex
苄噻嗪生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Ki: 8.0 nM (CA9), 8.8 nM (CA2), 10 nM (CA1)[2]
[体外研究]
[体内研究]
[参考文献]
[相关活性小分子]
苄噻嗪物理化学性质
[ 密度 ]:
1.4176 (rough estimate)
[ 沸点 ]:
680.6 °C at 760 mmHg
[ 熔点 ]:
231-232° (U.S. patent); mp 238-239° (P'an)
[ 分子式 ]:
C15H14ClN3O4S3
[ 分子量 ]:
431.93700
[ 闪点 ]:
365.4 °C
[ 精确质量 ]:
430.98300
[ PSA ]:
160.75000
[ LogP ]:
4.86900
[ 折射率 ]:
1.6100 (estimate)
[ 储存条件 ]:
室温
苄噻嗪MSDS
苄噻嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK8400000
- CHEMICAL NAME :
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)menthyl)-6-chloro-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 91-33-8
- LAST UPDATED :
- 199610
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C15-H14-Cl-N3-O4-S3
- MOLECULAR WEIGHT :
- 431.95
- WISWESSER LINE NOTATION :
- T66 BSWM ENJ D1S1R& HG ISZW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,122,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 422 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,122,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,778,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 410 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,122,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,122,1960
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,122,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84680 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
苄噻嗪安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H317-H334
[ 警示性声明 ]:
P261-P280-P342 + P311
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
42/43
[ 安全声明 (欧洲) ]:
26-36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
DK8400000
[ 海关编码 ]:
2935009090
苄噻嗪海关
[ 海关编码 ]: 2935009090
[ 中文概述 ]:
2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
苄噻嗪文献
J. Capill. Electrophor. Microchip Technol. 6(5-6) , 163-8, (1999)
Interactions between diuretics and a recently synthesized temperature-responsive neutral copolymer, poly(N-isopropyl acrylamide) (PNIPA) grafted with poly(ethyleneoxide) (PEO) (PNIPA-g-PEO) were inves...
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug.BMC Syst. Biol. 6 , 80, (2012)
The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical i...
Rapid screening for diuretic doping agents in urine by C60-assisted laser-desorption-ionization-time-of-flight mass spectrometry.J. Anal. Toxicol. 23(5) , 337-42, (1999)
This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are dir...
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Benzthiazide
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥1000.0/500mg
联系人:李先生
产品详情:苄噻嗪
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥720.9/1ml
¥199.9/250mg
¥需询单/1g
¥需询单/1g
联系人:阿拉丁李高志
产品详情:苯并噻嗪
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥395.0/1g
联系人:夏言
产品详情:[Perfemiker]苄噻嗪,95%
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相关化合物
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