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岩藻多糖

岩藻多糖用途

褐藻糖胶是一种具有生物活性的多糖,是α-淀粉酶和α-葡萄糖苷酶的有效抑制剂。抗凝血、抗肿瘤、抗氧化和抗疲劳活性[1]。

岩藻多糖名称

[ CAS 号 ]:
9072-19-9

[ 中文名 ]:
岩藻聚糖硫酸酯

[ 英文名 ]:
Fucoidan

[中文别名 ]:

岩藻多糖

[英文别名 ]:

MFCD00131109

岩藻多糖生物活性

[ 描述 ]:

褐藻糖胶是一种具有生物活性的多糖,是α-淀粉酶和α-葡萄糖苷酶的有效抑制剂。抗凝血、抗肿瘤、抗氧化和抗疲劳活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 心血管疾病

研究领域 >> 代谢疾病

[体外研究]

褐藻糖胶是一种生物活性多糖,大量存在于褐藻中[1]。从结藻中提取的岩藻糖胶是一种更有效的α-葡萄糖苷酶抑制剂,其IC50范围为0.013至0.047 mg/mL,比从水泡囊藻中提取的岩藻糖胶的抑制作用(IC50=0.049 mg/mL)。从泡囊藻中提取的岩藻糖胶不抑制α-淀粉酶活性,而从结藻中提取的岩藻糖胶在5 mg/mL浓度下降低α-淀粉酶活性7-100%,具体取决于藻类收获期。结藻褐藻糖胶抑制α-淀粉酶的IC50为0.12-4.64 mg/mL[1]。岩藻糖胶是一种富含岩藻糖的硫酸多糖,通常存在于海藻的细胞壁中,但最近也从陆地来源分离出来。褐藻糖胶对与氧化应激相关的多种代谢性疾病具有诱人的治疗潜力[2]。

[体内研究]

褐藻糖胶(单次注射25mg/kg/体)不抑制肿瘤细胞增殖,而三次注射10mg/kg/体可显著降低肿瘤生长和转移[3]。动物模型：小鼠[3]剂量：10-400mg/kg给药：腹腔注射；其次是全身照射结果：注射100mg/kg的小鼠在照射后30d的存活率最高。

[参考文献]

[1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33.

[2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467.

[3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46.

岩藻多糖物理化学性质

[ 分子式 ]:
C₇H₁₄O₇S

[ 分子量 ]:
242.24700

[ 精确质量 ]:
242.04600

[ PSA ]:
121.67000

[ 外观性状 ]:
白色至淡黄色粉末

[ 储存条件 ]:
室温

岩藻多糖MSDS

详细MSDS(安全技术说明书)

岩藻多糖安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
34

[ 安全声明 (欧洲) ]:
26-27-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

岩藻多糖文献

Antiproliferative activity of fucan nanogel.

Mar. Drugs 10(9) , 2002-22, (2012)

Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated L-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses. To that end, a n...

Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI.

Arterioscler. Thromb. Vasc. Biol. 34(8) , 1661-7, (2014)

Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic plaques have a strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques, but no...

Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.

Br. J. Nutr. 110(5) , 880-90, (2013)

Laminaria japonica is traditionally eaten in Japan as a beneficial food for thrombosis. The alga contains two specific ingredients, a xanthophyll fucoxanthin (FX) and a polysaccharide, F-fucoidan (FD)...

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