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聚乙二醇硬脂酸酯

聚乙二醇硬脂酸酯用途

Polyoxyethylene stearate (POES) 是非离子乳化剂。

聚乙二醇硬脂酸酯名称

[ CAS 号 ]:
9004-99-3

[ 中文名 ]:
聚乙二醇单硬脂酸酯

[ 英文名 ]:
Polyoxyethylene stearate

[中文别名 ]:

[英文别名 ]:

Ethylene glycol, monostearate
Stearic acid, 2-hydroxyethyl ester
MFCD00151755
2-Hydroxyethyl octadecanoate
2-Hydroxyethyl stearate
ETHYLENE GLYCOL MONOSTEARATE
Octadecanoic acid, 2-hydroxyethyl ester
Polyoxyethylene stearate

聚乙二醇硬脂酸酯生物活性

[ 描述 ]:

Polyoxyethylene stearate (POES) 是非离子乳化剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> P-糖蛋白

研究领域 >> 癌症

[体外研究]

聚氧乙烯硬脂酸酯已被推荐作为放射性标记的7H12 Middlebrook TB培养基的添加剂,因此已被证明可增强放射性BACTEC快速培养系统中分枝杆菌的生长。聚氧乙烯(50)硬脂酸盐对结核分枝杆菌和聚氧乙烯(30)硬脂酸酯和聚氧乙烯(JL)硬脂酸盐的生长的生长和减少所需的时间减少,用于除结核分枝杆菌以外的分枝杆菌物种[1]。聚氧乙烯硬脂酸酯主要通过调节底物刺激的P-gp ATP酶活性以浓度依赖性方式抑制P-gp介导的外排[2]。聚氧乙烯40硬脂酸盐减少长春碱硫酸盐efllux。当细胞用100或150μg/ mL聚氧乙烯40硬脂酸酯共同处理时,长春碱对K562/ADR细胞的细胞毒性显着增强[3]。

[体内研究]

聚氧乙烯硬脂酸酯可用作药物成分,以改善共同施用的P-gp底物和某些CYP同种型底物的口服生物利用度[2]。聚氧乙烯40硬脂酸酯+长春碱组的平均肿瘤体积和平均肿瘤重量显着较小。肿瘤生长的抑制率从0.06(长春碱组)增加到0.84(长春碱+聚氧乙烯40硬脂酸酯组)[3]。

[细胞实验]

将聚氧乙烯40硬脂酸酯加入到测试长春碱溶液中。然后评估长春碱对K562 / ADR细胞的细胞毒性。聚氧乙烯40硬脂酸酯的最终浓度为0,50,100和150μg/ mL。处理8小时后，将细胞在MTT试剂存在下孵育4小时，然后用DMSO裂解。吸光度测量值为490 nM [3]。

[动物实验]

小鼠：将聚氧乙烯40硬脂酸酯和长春碱溶解在0.9％氯化钠溶液中，得到200μg/ mL VBL和150μg/ mL PS40的溶液。每隔一天以2mg / kg长春碱和1.5mg / kg聚氧乙烯40硬脂酸盐的剂量皮下注射药物，每10g体重0.1mL，持续8天。从肿瘤形成的那天起每天测量肿瘤体积和小鼠体重[3]。

[参考文献]

[1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20.

[2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

[3]. Luo L, et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35.

[相关活性小分子]

聚乙二醇硬脂酸酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
438.4±18.0 °C at 760 mmHg

[ 熔点 ]:
47ºC

[ 分子式 ]:
C₂₀H₄₀O₃

[ 分子量 ]:
328.530

[ 闪点 ]:
164.6±14.0 °C

[ 精确质量 ]:
328.297760

[ PSA ]:
46.53000

[ LogP ]:
7.85

[ 外观性状 ]:
淡琥珀色半固体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.457

[ 储存条件 ]:
室温

聚乙二醇硬脂酸酯MSDS

详细MSDS(安全技术说明书)

聚乙二醇硬脂酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TQ5950000

CHEMICAL NAME :: Polyethylene glycol monostearate #6000

CAS REGISTRY NUMBER :: 9004-99-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80463 No. of Facilities: 2667 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 40362 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81475 No. of Facilities: 1026 (estimated) No. of Industries: 7 No. of Occupations: 6 No. of Employees: 15937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8317 No. of Facilities: 9882 (estimated) No. of Industries: 71 No. of Occupations: 99 No. of Employees: 608690 (estimated) No. of Female Employees: 461354 (estimated)

聚乙二醇硬脂酸酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
MD0907300

聚乙二醇硬脂酸酯制备

1.将1.07mol聚乙二醇、0.49mol硼酸投入反应釜中，加热至110℃，抽真空至0.67kPa，反应2h，生成硼酸酯。然后加入对甲苯磺酸做催化剂，再加入1mol硬脂酸。在140℃下反应3～4h后，取样测酸值，当酸值降低到10mgKOH/g左右反应结束。再将料液进行中和后放掉废水，趁热搅拌成型，冷却后包装即为成品。

C17H35COOH+HO(CH2CH2O)nH

C17H35COO(CH2CH2O)nH+H2O

聚乙二醇硬脂酸酯文献

In Vivo Transfection and Detection of Gene Expression of Stem Cells Preloaded with DNA-carrying Microbubbles.

Radiology 276 , 518-25, (2015)

To determine whether (a) stem cells loaded with DNA-carrying microbubbles (MBs) can be transfected in vivo, (b) the cells remain alive to express the gene, and (c) gene expression is sufficiently robu...

Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process.

Int. J. Nanomedicine 6 , 2997-3009, (2011)

The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical a...

[9-nitrocamptothecin nanostructured lipid carrier system: in vitro releasing characteristics, uptake by cells, and tissue distribution in vivo].

Yao Xue Xue Bao 40(11) , 970-5, (2005)

To study the release and cell uptake characteristics of 9-nitrocamptothecin (9-NC) nanostructured lipid carrier system (NLC) in vitro and its tissue distribution characteristics in vivo.Mouse peritone...

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