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盐酸地托咪定

盐酸地托咪定用途

Detomidine是α2-肾上腺素激动剂。

盐酸地托咪定名称

[ CAS 号 ]:
90038-01-0

[ 中文名 ]:
盐酸地托咪定

[ 英文名 ]:
Detomidine hydrochloride

[中文别名 ]:

[英文别名 ]:

盐酸地托咪定生物活性

[ 描述 ]:

Detomidine是α2-肾上腺素激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[参考文献]

[1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

[相关活性小分子]

盐酸地托咪定物理化学性质

[ 沸点 ]:
386.5ºC at 760mmHg

[ 熔点 ]:
160ºC

[ 分子式 ]:
C₁₂H₁₅ClN₂

[ 分子量 ]:
222.714

[ 闪点 ]:
200.6ºC

[ 精确质量 ]:
222.092377

[ PSA ]:
28.68000

[ LogP ]:
3.41930

[ 储存条件 ]:
室温，干燥

盐酸地托咪定MSDS

详细MSDS(安全技术说明书)

盐酸地托咪定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5160000

CHEMICAL NAME :: 1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 90038-01-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2.Cl-H

MOLECULAR WEIGHT :: 222.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4443466

盐酸地托咪定安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
NI5160000

[ 海关编码 ]:
2933290090

盐酸地托咪定海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸地托咪定文献

Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.

J. Vet. Pharmacol. Ther. 34(5) , 508-11, (2011)

Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses.

Vet. Anaesth. Analg. 40(4) , 375-81, (2013)

To compare the changes in splenic length and thickness and in packed cell volume (PCV) following detomidine or xylazine administration and subsequent epinephrine infusion.Spleen relaxation occurs foll...

Comparison of the mechanical hypoalgesic effects of five α2-adrenoceptor agonists in donkeys.

Vet. Rec. 173(12) , 294, (2013)

Pharmacological pain management is necessary under many clinical situations, but in donkeys little information on analgesic drugs is available. This controlled, randomised, crossover, Latin-square, op...

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