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DL-苄基丁二酸

DL-苄基丁二酸用途

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) 是一种有效的羧肽酶 A (CPA) 抑制剂。

DL-苄基丁二酸名称

[ CAS 号 ]:
884-33-3

[ 中文名 ]:
α-苄基丁二酸

[ 英文名 ]:
2-Benzylsuccinic acid

[中文别名 ]:

[英文别名 ]:

Butanedioic acid, 2-(phenylmethyl)-
2-Benzylsuccinic acid
Benzyl butanedioic acid
DL-BENZYLSUCCINIC ACID
alpha-Benzylsuccinic acid
2-benzylbutanedioic acid
MFCD00055798

DL-苄基丁二酸生物活性

[ 描述 ]:

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) 是一种有效的羧肽酶 A (CPA) 抑制剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 羧

[参考文献]

[1]. Mark P. Wentland, et al. 96-Well Plate Colorimetric Assay for Ki Determination of (+/-)-2-Benzylsuccinic Acid, an Inhibitor of Carboxypeptidase A: A Laboratory Experiment in Drug Discovery. J Chem Educ. 2004 Mar 1, 81 (3):398.

DL-苄基丁二酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
331.4±22.0 °C at 760 mmHg

[ 熔点 ]:
161-163°C

[ 分子式 ]:
C₁₁H₁₂O₄

[ 分子量 ]:
208.211

[ 闪点 ]:
168.4±18.8 °C

[ 精确质量 ]:
208.073563

[ PSA ]:
74.60000

[ LogP ]:
1.60

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
室温，干燥密封

DL-苄基丁二酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2917399090

DL-苄基丁二酸海关

[ 海关编码 ]: 2917399090

[ 中文概述 ]:
2917399090 其他芳香多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

DL-苄基丁二酸文献

Regulation of cytoplasmic tubulin carboxypeptidase activity in vitro by cations and sulfhydryl-modifying compounds.

J. Cell. Biochem. 60(3) , 424-36, (1996)

alpha-tubulin subunits within microtubules (MTs) can be post-translationally detyrosinated by a tubulin-specific carboxypeptidase (TCP) activity to form biochemically distinct MTs. Attempts to charact...

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

PLoS ONE 6(4) , e19270, (2011)

Nerve injury leads to sensitization mechanisms in the peripheral and central nervous system which involve transcriptional and post-transcriptional modifications in sensory nerves. To assess protein re...

The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.

EMBO J. 16(23) , 6906-13, (1997)

The three-dimensional structure of human procarboxypeptidase A2 has been determined using X-ray crystallography at 1.8 A resolution. This is the first detailed structural report of a human pancreatic ...

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