来普霉素B

来普霉素B用途

Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1 失活。 Leptomycin B 是一种有效的抗真菌抗生素,可阻断真核细胞周期。

来普霉素B名称

[ CAS 号 ]:
87081-35-4

[ 中文名 ]:
来普霉素B

[ 英文名 ]:
Leptomycin B

[英文别名 ]:

2,10,12,16,18-nonadecapentaenoic acid
antibioticci940
antibioticcl1957a
LEPTOMYCIN B FROM STREPTOMYCES SP
Leptomycin B

来普霉素B生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 跨膜转运 >> CRM1

[ 靶点 ]

CRM1/exportin 1[1]

[参考文献]

[1]. Kudo N, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7.

来普霉素B物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
725.8±60.0 °C at 760 mmHg

[ 熔点 ]:
41-44ºC

[ 分子式 ]:
C₃₃H₄₈O₆

[ 分子量 ]:
540.73

[ 闪点 ]:
224.8±26.4 °C

[ 精确质量 ]:
540.345093

[ PSA ]:
100.90000

[ LogP ]:
6.66

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±5.3 mmHg at 25°C

[ 折射率 ]:
1.542

来普霉素B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5390000

CHEMICAL NAME :: 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethy l- 6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-

CAS REGISTRY NUMBER :: 87081-35-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C33-H48-O6

MOLECULAR WEIGHT :: 540.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,253,1985

来普霉素B安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301-H311-H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
T: Toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
7-16-24-33-45

[ 危险品运输编码 ]:
UN 1230 3

[ WGK德国 ]:
3

[ 海关编码 ]:
2916190090

来普霉素B合成路线

详细合成路线

来普霉素B上下游产品

来普霉素B上游产品

来普霉素B下游产品

来普霉素B海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

来普霉素B文献

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.

Virology 474 , 82-93, (2014)

Topoisomerases modulate the topological state of DNA during processes, such as replication and transcription, that cause overwinding and/or underwinding of the DNA. African swine fever virus (ASFV) is...

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.

Nat. Commun. 5 , 5437, (2014)

Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instabilit...

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