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2,4-喹唑啉二酮

2,4-喹唑啉二酮用途

Benzoyleneurea 拥有抗菌活性。Benzoyleneurea 支架常被用作合成新型 PGGTase-I 的抑制剂。

2,4-喹唑啉二酮名称

[ CAS 号 ]:
86-96-4

[ 中文名 ]:
2,4-喹唑啉二酮

[ 英文名 ]:
Benzoyleneurea

[中文别名 ]:

[英文别名 ]:

1H,3H-quinazoline-2,4-dione
2-keto-4-quinazolinone
1H-quinazoline-2,4-dione
quinazolinedione
Quinazoline-2,4-dione
benzouracil
4-Dihydroxy quinazoline
2,4-dioxo-1,2,3,4-tetrahydroquinazoline
quinazolin-2,4(1H,3H)-dione
2,4-quinazolinediol

2,4-喹唑啉二酮生物活性

[ 描述 ]:

Benzoyleneurea 拥有抗菌活性。Benzoyleneurea 支架常被用作合成新型 PGGTase-I 的抑制剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Carrico D, et al. Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. Bioorg Med Chem. 2005 Feb 1;13(3):677-88.

2,4-喹唑啉二酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
491.9ºC at 760 mmHg

[ 熔点 ]:
300 °C(lit.)

[ 分子式 ]:
C₈H₆N₂O₂

[ 分子量 ]:
162.145

[ 精确质量 ]:
162.042923

[ PSA ]:
65.72000

[ LogP ]:
0.55

[ 外观性状 ]:
白色至淡粉红色松软的粉末

[ 折射率 ]:
1.587

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶

2,4-喹唑啉二酮MSDS

详细MSDS(安全技术说明书)

2,4-喹唑啉二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA1390000

CHEMICAL NAME :: 2,4(1H,3H)-Quinazolinedione

CAS REGISTRY NUMBER :: 86-96-4

LAST UPDATED :: 199112

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H6-N2-O2

MOLECULAR WEIGHT :: 162.16

WISWESSER LINE NOTATION :: T66 BMVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 3,100,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1447 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 17400 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966

2,4-喹唑啉二酮安全信息

[ 安全声明 (欧洲) ]:
S24/25-S22

[ WGK德国 ]:
2

[ RTECS号 ]:
VA1390000

[ 海关编码 ]:
2933990090

2,4-喹唑啉二酮合成路线

详细合成路线

2,4-喹唑啉二酮上下游产品

2,4-喹唑啉二酮上游产品

2,4-喹唑啉二酮下游产品

2,4-喹唑啉二酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%