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Ethotoin

Ethotoin用途

乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。

Ethotoin名称

[ CAS 号 ]:
86-35-1

[ 中文名 ]:
乙苯妥英

[ 英文名 ]:
Ethotoin

[中文别名 ]:

[英文别名 ]:

Ethotoin生物活性

[ 描述 ]:

乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 神经疾病

[体内研究]

在妊娠第18天给药后,乙素(口服灌胃；600 mg/kg；一次)会导致子代的轻微死亡率和体重减轻[2]。动物模型：妊娠Sprague-Dawley CD大鼠[2]剂量：600 mg/kg给药：灌胃；600毫克/千克；一次性结果：伊索酮断奶前死亡率为2.0%,接触伊索酮的动物体重比对照组低约6.6%。

[参考文献]

[1]. A S Troupin, et al. Clinical pharmacology of mephenytoin and ethotoin. Ann Neurol. 1979 Nov;6(5):410-4.

[2]. D R Minck, et al. Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Teratology. 1991 Apr;43(4):279-93.

Ethotoin物理化学性质

[ 密度 ]:
1.197 g/cm1.197 g/cm3

[ 沸点 ]:
342.72°C (rough estimate)

[ 熔点 ]:
94ºC

[ 分子式 ]:
C11H12N2O2

[ 分子量 ]:
204.22500

[ 精确质量 ]:
204.09000

[ PSA ]:
52.90000

[ LogP ]:
0.87730

[ 折射率 ]:
1.555

[ 储存条件 ]:
-20°C，密闭，干燥

Ethotoin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU2450000
CHEMICAL NAME :
Hydantoin, 3-ethyl-5-phenyl-
CAS REGISTRY NUMBER :
86-35-1
BEILSTEIN REFERENCE NO. :
0188272
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C11-H12-N2-O2
MOLECULAR WEIGHT :
204.25
WISWESSER LINE NOTATION :
T5MVNV EHJ C2 ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
923 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7200 mg/kg
SEX/DURATION :
female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 43,279,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7200 mg/kg
SEX/DURATION :
female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 43,279,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1194 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
858 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1195 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979

Ethotoin安全信息

[ 风险声明 (欧洲) ]:
22

Ethotoin合成路线

详细合成路线

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区域：上海市嘉定区

价格：
￥1440.0/10mg ￥2576.0/25mg ￥762.0/5mg ￥需询单/1g

联系人：李先生

产品详情：Ethotoin

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥205.9/1mg ￥6732.9/100mg ￥1099.9/10mg ￥2199.9/25mg

联系人：阿拉丁李高志

产品详情：Ethotoin

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥2060.0/5mg

联系人：夏言

产品详情：[Perfemiker]Ethotoin,98%

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