86-35-1

• 常用中文名：Ethotoin
• 常用英文名：Ethotoin
• CAS号：86-35-1
• 分子式：C₁₁H₁₂N₂O₂
• 分子量：204.22500
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 氟吡啶
• 发布时间：2018-07-02 17:35:41
• 更新时间：2024-01-03 05:39:26
• 乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。

名称

• 中文名: 乙苯妥英
• 英文名: ethotoin
• 中文别名: 乙基苯妥英
• 英文别名: Etotoina; Accenon; Peganone; Ethotoinum; 3-Ethyl-5-phenylhydantoin; 3-Aethyl-5-phenyl-imidazolidin-2,4-dion; 3-ethyl-5-phenylimidazolidine-2,4-dione; Pegoanone; Ethotoine; 3-ethyl-5-phenyl-imidazolidine-2,4-dione

物化性质

• 密度: 1.197 g/cm1.197 g/cm3
• 沸点: 342.72°C (rough estimate)
• 熔点: 94ºC
• 分子式: C₁₁H₁₂N₂O₂
• 分子量: 204.22500
• 精确质量: 204.09000
• PSA: 52.90000
• LogP: 0.87730
• 折射率: 1.555
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 乙素(聚乙二醇酮)是一种用于癫痫研究的口服活性抗惊厥剂,乙素是乙内酰脲,类似于苯妥英钠[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 在妊娠第18天给药后,乙素(口服灌胃；600 mg/kg；一次)会导致子代的轻微死亡率和体重减轻[2]。动物模型：妊娠Sprague-Dawley CD大鼠[2]剂量：600 mg/kg给药：灌胃；600毫克/千克；一次性结果：伊索酮断奶前死亡率为2.0%,接触伊索酮的动物体重比对照组低约6.6%。
• 参考文献:

  [1]. A S Troupin, et al. Clinical pharmacology of mephenytoin and ethotoin. Ann Neurol. 1979 Nov;6(5):410-4.

  [2]. D R Minck, et al. Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Teratology. 1991 Apr;43(4):279-93.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MU2450000 CHEMICAL NAME : Hydantoin, 3-ethyl-5-phenyl- CAS REGISTRY NUMBER : 86-35-1 BEILSTEIN REFERENCE NO. : 0188272 LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C11-H12-N2-O2 MOLECULAR WEIGHT : 204.25 WISWESSER LINE NOTATION : T5MVNV EHJ C2 ER HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 625 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 923 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1060 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,117,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7200 mg/kg SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 43,279,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7200 mg/kg SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - other neonatal measures or effects REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 43,279,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 1194 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 858 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 1195 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979

安全

• 风险声明 (欧洲): 22

合成路线

74-96-4 ~% 86-35-1

文献：Chemische Berichte, , vol. 21, p. 2324 Justus Liebigs Annalen der Chemie, , vol. 350, p. 135

2935-35-5 109-90-0 ~% 86-35-1

文献：Canadian Journal of Chemistry, , vol. 66, # 11 p. 2751 - 2762

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