米托唑胺
米托唑胺名称
[ CAS 号 ]:
85622-95-3
[ 中文名 ]:
米托唑胺
[ 英文名 ]:
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,3-(2-chloroethyl)-3,4-dihydro-4-oxo-
[英文别名 ]:
- Azolastone
- Mitozolamide
- Mitozolomide
米托唑胺物理化学性质
[ 密度 ]:
1.94g/cm3
[ 沸点 ]:
555.8ºC at 760 mmHg
[ 分子式 ]:
C7H7ClN6O2
[ 分子量 ]:
242.62200
[ 闪点 ]:
289.9ºC
[ 精确质量 ]:
242.03200
[ PSA ]:
108.17000
[ 折射率 ]:
1.834
米托唑胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NJ5927000
- CHEMICAL NAME :
- Imidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-
- CAS REGISTRY NUMBER :
- 85622-95-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C7-H7-Cl-N6-O2
- MOLECULAR WEIGHT :
- 242.65
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 3108 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Blood - changes in cell count (unspecified) Blood - changes in bone marrow (not otherwise specified) Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1767,1984
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