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5-氨基-4-甲酰胺咪唑

5-氨基-4-甲酰胺咪唑用途

5-Amino-3H-imidazole-4-Carboxamide (AICA) 是合成嘌呤的重要前体,尤其是核碱基腺嘌呤和鸟嘌呤。

5-氨基-4-甲酰胺咪唑名称

[ CAS 号 ]:
360-97-4

[ 中文名 ]:
5-氨基-4-咪唑甲酰胺

[ 英文名 ]:
5-Amino-4-imidazolecarboxamide

[中文别名 ]:

[英文别名 ]:

4-AMino-5-carbaMoyliMidazole
4(5)-aminoimidazole-5(4)-carboxamide
5-aminoimidazole-4-carboxamide
diazol-c
5-amino-4-imidazole carboxamide
4-Amino-5-imidazolecarboxamide
T5M CNJ DVZ EZ
MFCD02181040
EINECS 206-641-4
4-aminoimidazole-5-carboxamide

5-氨基-4-甲酰胺咪唑生物活性

[ 描述 ]:

5-Amino-3H-imidazole-4-Carboxamide (AICA) 是合成嘌呤的重要前体,尤其是核碱基腺嘌呤和鸟嘌呤。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. YANG LIU. VARIABLE-TEMPERATURE 1 H-NMR AND AB INITIO STUDY OF 5-AMINO-IMIDAZOLE-4-CARBOXAMIDE (AICA): COMPETING PATHS FOR AMIDE-H SCRAMBLING. DECEMBER 2008.

[相关活性小分子]

5-氨基-4-甲酰胺咪唑物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
535.4±60.0 °C at 760 mmHg

[ 熔点 ]:
164-170 °C(lit.)

[ 分子式 ]:
C₄H₆N₄O

[ 分子量 ]:
126.117

[ 闪点 ]:
277.6±32.9 °C

[ 精确质量 ]:
126.054161

[ PSA ]:
97.79000

[ LogP ]:
-1.01

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.799

[ 储存条件 ]:
库房通风低温干燥

5-氨基-4-甲酰胺咪唑MSDS

详细MSDS(安全技术说明书)

5-氨基-4-甲酰胺咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3910000

CHEMICAL NAME :: Imidazole-4-carboxamide, 5-amino-

CAS REGISTRY NUMBER :: 360-97-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H6-N4-O

MOLECULAR WEIGHT :: 126.14

WISWESSER LINE NOTATION :: T5M CNJ DVZ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22750 mg/kg/13W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2275 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6390 mg/kg/21W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 3 mmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

5-氨基-4-甲酰胺咪唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NI3910000

[ 海关编码 ]:
2934999090

5-氨基-4-甲酰胺咪唑上下游产品

5-氨基-4-甲酰胺咪唑上游产品

5-氨基-4-甲酰胺咪唑下游产品

5-氨基-4-甲酰胺咪唑制备

用α-脒基-α-甲酰氨基乙酰胺盐酸盐在溶剂如二甲苯中环合制得。

5-氨基-4-甲酰胺咪唑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氨基-4-甲酰胺咪唑文献

Differential effects of AMPK agonists on cell growth and metabolism.

Oncogene 34 , 3627-39, (2015)

As a sensor of cellular energy status, the AMP-activated protein kinase (AMPK) is believed to act in opposition to the metabolic phenotypes favored by proliferating tumor cells. Consequently, compound...

Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.

J. Nutr. 144(12) , 1887-95, (2014)

Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nut...

Molecular characterization, fitness and mycotoxin production of benzimidazole-resistant isolates of Penicillium expansum.

Int. J. Food Microbiol. 162(3) , 237-44, (2013)

Penicillium expansum field-strains resistant to benzimidazole fungicides were isolated in high frequency from decayed apple fruit collected from packinghouses and processing industries located in the ...

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