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氯乙基异氰酸酯

氯乙基异氰酸酯用途

【用途一】
亚硝基脲类抗肿瘤药物的合成。

氯乙基异氰酸酯名称

[ CAS 号 ]:
1943-83-5

[ 中文名 ]:
氯乙基异氰酸酯

[ 英文名 ]:
1-Chloro-2-isocyanatoethane

[中文别名 ]:

[英文别名 ]:

CHLOROETHYLISOCYANATE
1-Chloro-2-isocyanatoethane
2-chlorethylisokyanat
2-chloroethyl isothiocyanate
Isocyanic Acid 2-Chloroethyl Ester
Chlorine ethyl isocyanate
Ethane, 1-chloro-2-isocyanato-
N-2-chloroethyl isocyanate
b-Chloroethylisocyanate
MFCD00002043

氯乙基异氰酸酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
135.0±0.0 °C at 760 mmHg

[ 熔点 ]:
135ºC

[ 分子式 ]:
C₃H₄ClNO

[ 分子量 ]:
105.523

[ 闪点 ]:
56.7±0.0 °C

[ 精确质量 ]:
104.998138

[ PSA ]:
29.43000

[ LogP ]:
1.43

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
7.9±0.2 mmHg at 25°C

[ 折射率 ]:
1.456

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but moisture sensitive. Combustible. Incompatible with water, moisture, strong oxidizing agents, strong bases, acids, alcohols, amines.

[ 水溶解性 ]:
reacts

氯乙基异氰酸酯MSDS

详细MSDS(安全技术说明书)

氯乙基异氰酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ8450000

CHEMICAL NAME :: Isocyanic acid, 2-chloroethyl ester

CAS REGISTRY NUMBER :: 1943-83-5

BEILSTEIN REFERENCE NO. :: 1071429

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C3-H4-Cl-N-O

MOLECULAR WEIGHT :: 105.53

WISWESSER LINE NOTATION :: OCN2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 13 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,3379,1978

氯乙基异氰酸酯安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301 + H331-H315-H319-H334-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R34;R42

[ 安全声明 (欧洲) ]:
S26-S36-S45-S38-S36/37/39-S28A-S23

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NQ8450000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2929109000

氯乙基异氰酸酯上下游产品

氯乙基异氰酸酯上游产品

氯乙基异氰酸酯下游产品

氯乙基异氰酸酯海关

[ 海关编码 ]: 2929109000

[ 中文概述 ]:
2929109000. 其他异氰酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氯乙基异氰酸酯文献

Uniform small graphene oxide as an efficient cellular nanocarrier for immunostimulatory CpG oligonucleotides.

ACS Appl. Mater. Interfaces 6(10) , 7926-32, (2014)

Graphene oxide (GO) has attracted more and more attention as a promising nanomaterial in biomedical research and applications. In this study, we explore the ability of GO as nanocarrier for synthetic ...

Isocyanate binding to yeast glutathione reductase measured by fluorescence spectroscopy.

Biochem. Soc. Trans. 25(1) , 47S, (1997)

Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates.

Biochem. Pharmacol. 36(21) , 3731-8, (1987)

We present a novel dynamic flow cytoenzymological demonstration of the potent inhibition by the antitumour chloroethylnitrosourea BCNU of the intracellular hydrolysis of fluorescein diacetate by ester...

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