ILMOFOSINE

ILMOFOSINE名称

[ CAS 号 ]:
83519-04-4

[ 英文名 ]:
ILMOFOSINE

ILMOFOSINE物理化学性质

[ 分子式 ]:
C₂₆H₅₆NO₅PS

[ 分子量 ]:
525.76500

[ 精确质量 ]:
525.36200

[ PSA ]:
102.93000

[ LogP ]:
7.74150

ILMOFOSINEMSDS

ILMOFOSINE毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JH4758000

CHEMICAL NAME :: 3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-7-(methoxymethyl)-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide

CAS REGISTRY NUMBER :: 83519-04-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C26-H56-N-O5-P-S

MOLECULAR WEIGHT :: 525.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 253 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 615 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mg/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5538,1983

ILMOFOSINE安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
JH4758000

ILMOFOSINE合成路线

ILMOFOSINE文献

Phase I trial of ilmofosine as a 24 hour infusion weekly.

Invest. New Drugs 13(3) , 205-10, (1995)

Ilmofosine, an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. Maximum efficacy in preclinical models is associated with prolonged exposure to the d...

A phase II trial of ilmofosine in non-small cell bronchogenic carcinoma.

Invest. New Drugs 14(2) , 219-22, (1996)

We have conducted a study of ilmofosine (1-hexadecylthio; 2-methoxyethyl-rac-glycero-3-phosphocholine) in non-small cell bronchogenic carcinoma, using a schedule of continuous infusion for 5 days and ...

Structure-function relationships of alkyl-lysophospholipid analogs in selective antitumor activity.

Lipids 28(6) , 511-6, (1993)

This investigation was initiated in order to delineate the structure-function relationship of the anticancer alkyl-lysophospholipids and assess their degree of selective cytotoxicity toward neoplastic...

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